Background Angular stable plate fixation is a widely accepted treatment option for interprosthetic or periprosthetic femoral fractures with stable implants. This biomechanical study tries to establish a safe distance of the plate from the tip of a femoral prosthesis. Methods A total of 38 composite femurs were reamed to an inner diameter of 23 mm to create an osteoporotic bone model. A Weber hip stem was cemented into each and a distal femoral NCB plate applied with the distance to the stem varying from 8 cm apart to 6 cm overlap in 2-cm steps. Each specimen was tested in cyclic axial loading (400 N-1500 N) and then cyclic torsion (0.6 Nm-50 Nm). Peak strain on the femur around the tip of the plate was measured with a 3D image correlation system and averaged over 26 cycles (excluding the first 3 and the last cycles). Finally, each femur was axially loaded to failure. Results Strain increased with decreasing overlap or gap. Seven specimens failed early between 2-cm overlap and 2-cm gap. Results were divided into a far group with a distance of >4 cm and a close group of <4 cm. Strain was significantly higher in the close group for axial (P < .001) and torsional (P < .001) loading. Failure load was significantly lower in the close group (P = .002). Conclusion A minimal gap and/or overlap of at least 6 cm is recommended in osteoporotic bone to avoid stress risers.