Repetitive transcranial magnetic stimulation (rTMS) can modulate brain activity in humans, however, underlying mechanisms are unclear. This thesis examined low-intensity-rTMS (LI-rTMS) in mouse models of normal (wildtype) and abnormal neural circuitry (ephrin-A knockouts). Chronic Ll-rTMS did not affect learning or dendritic spine densities in normal systems. In ephrin-A2A5 knockouts, Ll-rTMS improved abnormal visual pathway topography and upregulated brain derived neurotrophic factor. Ll rTMS increased parvalbumin inhibitory neuron immunoreactivity in both genotypes, but increased visual cortical excitability only in wildtypes with concurrent visually-evoked activity. Results demonstrate network-level plasticity, linked to possible molecular mechanisms, and reveal interactions between Ll-rTMS and neural activity.
|Qualification||Doctor of Philosophy|
|Award date||28 Apr 2017|
|Publication status||Unpublished - 2017|