Plasticity induced by low-intensity repetitive transcranial magnetic stimulation: investigations in mouse models

Kalina Patricia Irena Makowiecki

doi:10.4225/23/591c02ea5f7e3

Plasticity induced by low-intensity repetitive transcranial magnetic stimulation: investigations in mouse models

Kalina Patricia Irena Makowiecki

Research output: Thesis › Doctoral Thesis

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) can modulate brain activity in humans, however, underlying mechanisms are unclear. This thesis examined low-intensity-rTMS (LI-rTMS) in mouse models of normal (wildtype) and abnormal neural circuitry (ephrin-A knockouts). Chronic Ll-rTMS did not affect learning or dendritic spine densities in normal systems. In ephrin-A2A5 knockouts, Ll-rTMS improved abnormal visual pathway topography and upregulated brain derived neurotrophic factor. Ll rTMS increased parvalbumin inhibitory neuron immunoreactivity in both genotypes, but increased visual cortical excitability only in wildtypes with concurrent visually-evoked activity. Results demonstrate network-level plasticity, linked to possible molecular mechanisms, and reveal interactions between Ll-rTMS and neural activity.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Rodger, Jennifer, Supervisor Thickbroom, Gary, Supervisor Harvey, Alan, Supervisor
Award date	28 Apr 2017
DOIs	https://doi.org/10.4225/23/591c02ea5f7e3
Publication status	Unpublished - 2017

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10.4225/23/591c02ea5f7e3

THESIS - DOCTOR OF PHILOSOPHY - MAKOWIECKI Kalina Patricia - 2017_Part_1
THESIS - DOCTOR OF PHILOSOPHY - MAKOWIECKI Kalina Patricia - 2017_Part_2
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Cite this

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title = "Plasticity induced by low-intensity repetitive transcranial magnetic stimulation: investigations in mouse models",

abstract = "Repetitive transcranial magnetic stimulation (rTMS) can modulate brain activity in humans, however, underlying mechanisms are unclear. This thesis examined low-intensity-rTMS (LI-rTMS) in mouse models of normal (wildtype) and abnormal neural circuitry (ephrin-A knockouts). Chronic Ll-rTMS did not affect learning or dendritic spine densities in normal systems. In ephrin-A2A5 knockouts, Ll-rTMS improved abnormal visual pathway topography and upregulated brain derived neurotrophic factor. Ll rTMS increased parvalbumin inhibitory neuron immunoreactivity in both genotypes, but increased visual cortical excitability only in wildtypes with concurrent visually-evoked activity. Results demonstrate network-level plasticity, linked to possible molecular mechanisms, and reveal interactions between Ll-rTMS and neural activity.",

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school = "The University of Western Australia",

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AU - Makowiecki, Kalina Patricia Irena

PY - 2017

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N2 - Repetitive transcranial magnetic stimulation (rTMS) can modulate brain activity in humans, however, underlying mechanisms are unclear. This thesis examined low-intensity-rTMS (LI-rTMS) in mouse models of normal (wildtype) and abnormal neural circuitry (ephrin-A knockouts). Chronic Ll-rTMS did not affect learning or dendritic spine densities in normal systems. In ephrin-A2A5 knockouts, Ll-rTMS improved abnormal visual pathway topography and upregulated brain derived neurotrophic factor. Ll rTMS increased parvalbumin inhibitory neuron immunoreactivity in both genotypes, but increased visual cortical excitability only in wildtypes with concurrent visually-evoked activity. Results demonstrate network-level plasticity, linked to possible molecular mechanisms, and reveal interactions between Ll-rTMS and neural activity.

AB - Repetitive transcranial magnetic stimulation (rTMS) can modulate brain activity in humans, however, underlying mechanisms are unclear. This thesis examined low-intensity-rTMS (LI-rTMS) in mouse models of normal (wildtype) and abnormal neural circuitry (ephrin-A knockouts). Chronic Ll-rTMS did not affect learning or dendritic spine densities in normal systems. In ephrin-A2A5 knockouts, Ll-rTMS improved abnormal visual pathway topography and upregulated brain derived neurotrophic factor. Ll rTMS increased parvalbumin inhibitory neuron immunoreactivity in both genotypes, but increased visual cortical excitability only in wildtypes with concurrent visually-evoked activity. Results demonstrate network-level plasticity, linked to possible molecular mechanisms, and reveal interactions between Ll-rTMS and neural activity.

KW - Non-invasive brain stimulation

KW - Plasticity

KW - Mouse model

KW - Magnetic stimulation

U2 - 10.4225/23/591c02ea5f7e3

DO - 10.4225/23/591c02ea5f7e3

M3 - Doctoral Thesis

ER -

Plasticity induced by low-intensity repetitive transcranial magnetic stimulation: investigations in mouse models

Abstract

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