Plasma micronutrient levels and telomere length in children

Elizabeth Milne, N.J. O'Callaghan, P. Ramankutty, Nicholas De Klerk, Kathryn Greenop, B.K. Armstrong, M.R. Miller, M.F. Fenech

Research output: Contribution to journalArticle

17 Citations (Scopus)
512 Downloads (Pure)

Abstract

© 2015 Elsevier Inc. Objective: Telomeres are long hexamer (TTAGGG) repeats at the ends of chromosomes, and contribute to maintenance of chromosomal stability. Telomere shortening has been linked to cancers and other chronic diseases in adults, although evidence for causal associations is limited. The aim of this study was to determine whether nutritional factors are associated with telomere length (TL) in children. Methods: We conducted a cross-sectional study of nutritional factors and TL in 437 children between 2009 and 2011. Healthy children ages 3, 6, and 9 y provided blood samples, and their parents completed a food frequency questionnaire and a telephone interview about relevant environmental exposures. TL and blood micronutrient levels were measured, and genotyping at 10 loci was undertaken. Associations between the micronutrients and other variables were assessed using linear regression. Results: No significant main or interactive effects of age or sex were seen. After adjustment for age, sex, parental education, and month of blood collection, TL was inversely associated with plasma zinc, and shorter in children with the homozygous mutant genotype of the RFC G80A (rs1051266) polymorphism. Conclusions: To the best of our knowledge, this is the first investigation of the association between telomere length and micronutrients in healthy children. The reason for the inverse relationship of TL with zinc is unknown but could be the result of an increase in telomere sequence deletions caused by labile zinc induction of oxidative stress. These findings should be corroborated in other studies before nutritional recommendations might be considered.
Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalNutrition
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 2015

Fingerprint Dive into the research topics of 'Plasma micronutrient levels and telomere length in children'. Together they form a unique fingerprint.

Cite this