TY - JOUR
T1 - Plasma lipoprotein subclass variation in middle-aged and older adults
T2 - Sex-stratified distributions and associations with health status and cardiometabolic risk factors
AU - Masuda, Reika
AU - Wist, Julien
AU - Lodge, Samantha
AU - Kimhofer, Torben
AU - Hunter, Michael
AU - Hui, Jennie
AU - Beilby, John P.
AU - Burnett, John R.
AU - Dwivedi, Girish
AU - Schlaich, Markus P.
AU - Bong, Sze How
AU - Loo, Ruey Leng
AU - Holmes, Elaine
AU - Nicholson, Jeremy K.
AU - Yeap, Bu B.
N1 - Copyright © 2023. Published by Elsevier Inc.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - BACKGROUND: Circulating lipids and lipoproteins mediate cardiovascular risk, however routine plasma lipid biochemistry provides limited information on pro-atherogenic remnant particles.OBJECTIVE: We analysed plasma lipoprotein subclasses including very low-density and intermediate-density lipoprotein (VLDL and IDL); and assessed their associations with health and cardiometabolic risk.METHODS: From 1,976 community-dwelling adults aged 45-67 years, 114/1071 women (10.6%) and 153/905 men (16.9%) were categorised as very healthy. Fasting plasma lipoprotein profiles comprising 112 parameters were measured using
1H nuclear magnetic resonance (NMR) spectroscopy, and associations with health status and cardiometabolic risk factors examined.
RESULTS: HDL cholesterol was higher, and IDL and VLDL cholesterol and triglycerides lower, in very healthy women compared to other women, and women compared to men. IDL and VLDL cholesterol and triglyceride were lower in very healthy men compared to other men. HDL cholesterol and apolipoprotein (apo) A-I were inversely, and IDL and VLDL cholesterol, apoB-100, and apoB-100/apoA-I ratio directly associated with body mass index (BMI) in women and men. In women, LDL, IDL and VLDL cholesterol increased with age. Women with diabetes and cardiovascular disease had higher cholesterol, triglycerides, phospholipids and free cholesterol across IDL and VLDL fractions, with similar trends for men with diabetes.CONCLUSION: Lipoprotein subclasses and density fractions, and their lipid and apolipoprotein constituents, are differentially distributed by sex, health status and BMI. Very healthy women and men are distinguished by favourable lipoprotein profiles, particularly lower concentrations of VLDL and IDL, providing reference intervals for comparison with general populations and adults with cardiometabolic risk factors.
AB - BACKGROUND: Circulating lipids and lipoproteins mediate cardiovascular risk, however routine plasma lipid biochemistry provides limited information on pro-atherogenic remnant particles.OBJECTIVE: We analysed plasma lipoprotein subclasses including very low-density and intermediate-density lipoprotein (VLDL and IDL); and assessed their associations with health and cardiometabolic risk.METHODS: From 1,976 community-dwelling adults aged 45-67 years, 114/1071 women (10.6%) and 153/905 men (16.9%) were categorised as very healthy. Fasting plasma lipoprotein profiles comprising 112 parameters were measured using
1H nuclear magnetic resonance (NMR) spectroscopy, and associations with health status and cardiometabolic risk factors examined.
RESULTS: HDL cholesterol was higher, and IDL and VLDL cholesterol and triglycerides lower, in very healthy women compared to other women, and women compared to men. IDL and VLDL cholesterol and triglyceride were lower in very healthy men compared to other men. HDL cholesterol and apolipoprotein (apo) A-I were inversely, and IDL and VLDL cholesterol, apoB-100, and apoB-100/apoA-I ratio directly associated with body mass index (BMI) in women and men. In women, LDL, IDL and VLDL cholesterol increased with age. Women with diabetes and cardiovascular disease had higher cholesterol, triglycerides, phospholipids and free cholesterol across IDL and VLDL fractions, with similar trends for men with diabetes.CONCLUSION: Lipoprotein subclasses and density fractions, and their lipid and apolipoprotein constituents, are differentially distributed by sex, health status and BMI. Very healthy women and men are distinguished by favourable lipoprotein profiles, particularly lower concentrations of VLDL and IDL, providing reference intervals for comparison with general populations and adults with cardiometabolic risk factors.
KW - Apolipoproteins
KW - Cardiovascular disease
KW - Cholesterol
KW - Diabetes
KW - Lipoproteins
KW - Nuclear magnetic resonance spectroscopy
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=85164395288&partnerID=8YFLogxK
U2 - 10.1016/j.jacl.2023.06.004
DO - 10.1016/j.jacl.2023.06.004
M3 - Article
C2 - 37442713
SN - 1933-2874
VL - 17
SP - 677
EP - 687
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
IS - 5
ER -
