Plasma ferritin concentrations are not associated with abdominal aortic aneurysm diagnosis, size or growth

J.V. Moxon, R.E. Jones, Paul E. Norman, P. Clancy, Leon Flicker, Osvaldo P. Almeida, Graeme J. Hankey, Bu B. Yeap, J. Golledge

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    Abstract

    © 2016.

    Background and aims: Experimental studies using a rodent model have suggested that iron overload may contribute to abdominal aortic aneurysm (AAA) pathogenesis. Methods: We assessed the association of total body iron, as measured by plasma ferritin, with AAA diagnosis, size and growth in 4024 community-dwelling older men screened for AAA, using logistic regression and linear mixed effects models. Results: Plasma ferritin concentrations were similar in men who did (n = 293) and did not (n = 3731) have an AAA (median [inter-quartile range] concentrations 115.4 [63.0-203.1] and 128.5 [66.1-229.1] ng/mL respectively, p = 0.124). There was no association between plasma ferritin concentration and AAA diagnosis in unadjusted logistic regression (odds ratio (OR) for a 1 standard deviation increase: 0.880 [95%CI: 0.764-1.015]; p = 0.078), or when adjusting for AAA risk factors and factors known to influence circulating ferritin (OR for a 1 standard deviation increase: 0.898 [95% CI: 0.778-1.035]; p = 0.138). Iron overload prevalence (plasma ferritin concentrations >200 ng/mL) was lower in men with an AAA (25.3%) than those without (30.8%; p = 0.048), but was not associated with AAA diagnosis after adjusting as above (OR: 0.781 [95% CI:0.589-1.035]; p = 0.086). The association of iron overload with AAA growth was investigated in 265 men with small AAAs who received at least 1 repeat ultrasound scan in the 3 years following screening. We saw no difference in AAA growth between men who did and did not have iron overload (n = 65 and 185 respectively, p = 0.164). Conclusions: Our data suggest that iron overload is unlikely to be important in AAA pathogenesis.

    Original languageEnglish
    Pages (from-to)19-24
    JournalAtherosclerosis
    Volume251
    Early online date12 May 2016
    DOIs
    Publication statusPublished - Aug 2016

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    Abdominal Aortic Aneurysm
    Ferritins
    Iron Overload
    Growth
    Odds Ratio
    Logistic Models
    Independent Living
    Rodentia
    Iron

    Cite this

    @article{2e1e224e25b04cfb8346dd5f9d9027e7,
    title = "Plasma ferritin concentrations are not associated with abdominal aortic aneurysm diagnosis, size or growth",
    abstract = "{\circledC} 2016. Background and aims: Experimental studies using a rodent model have suggested that iron overload may contribute to abdominal aortic aneurysm (AAA) pathogenesis. Methods: We assessed the association of total body iron, as measured by plasma ferritin, with AAA diagnosis, size and growth in 4024 community-dwelling older men screened for AAA, using logistic regression and linear mixed effects models. Results: Plasma ferritin concentrations were similar in men who did (n = 293) and did not (n = 3731) have an AAA (median [inter-quartile range] concentrations 115.4 [63.0-203.1] and 128.5 [66.1-229.1] ng/mL respectively, p = 0.124). There was no association between plasma ferritin concentration and AAA diagnosis in unadjusted logistic regression (odds ratio (OR) for a 1 standard deviation increase: 0.880 [95{\%}CI: 0.764-1.015]; p = 0.078), or when adjusting for AAA risk factors and factors known to influence circulating ferritin (OR for a 1 standard deviation increase: 0.898 [95{\%} CI: 0.778-1.035]; p = 0.138). Iron overload prevalence (plasma ferritin concentrations >200 ng/mL) was lower in men with an AAA (25.3{\%}) than those without (30.8{\%}; p = 0.048), but was not associated with AAA diagnosis after adjusting as above (OR: 0.781 [95{\%} CI:0.589-1.035]; p = 0.086). The association of iron overload with AAA growth was investigated in 265 men with small AAAs who received at least 1 repeat ultrasound scan in the 3 years following screening. We saw no difference in AAA growth between men who did and did not have iron overload (n = 65 and 185 respectively, p = 0.164). Conclusions: Our data suggest that iron overload is unlikely to be important in AAA pathogenesis.",
    author = "J.V. Moxon and R.E. Jones and Norman, {Paul E.} and P. Clancy and Leon Flicker and Almeida, {Osvaldo P.} and Hankey, {Graeme J.} and Yeap, {Bu B.} and J. Golledge",
    year = "2016",
    month = "8",
    doi = "10.1016/j.atherosclerosis.2016.05.022",
    language = "English",
    volume = "251",
    pages = "19--24",
    journal = "Atherosclerosis",
    issn = "0021-9150",
    publisher = "Elsevier",

    }

    Plasma ferritin concentrations are not associated with abdominal aortic aneurysm diagnosis, size or growth. / Moxon, J.V.; Jones, R.E.; Norman, Paul E.; Clancy, P.; Flicker, Leon; Almeida, Osvaldo P.; Hankey, Graeme J.; Yeap, Bu B.; Golledge, J.

    In: Atherosclerosis, Vol. 251, 08.2016, p. 19-24.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Plasma ferritin concentrations are not associated with abdominal aortic aneurysm diagnosis, size or growth

    AU - Moxon, J.V.

    AU - Jones, R.E.

    AU - Norman, Paul E.

    AU - Clancy, P.

    AU - Flicker, Leon

    AU - Almeida, Osvaldo P.

    AU - Hankey, Graeme J.

    AU - Yeap, Bu B.

    AU - Golledge, J.

    PY - 2016/8

    Y1 - 2016/8

    N2 - © 2016. Background and aims: Experimental studies using a rodent model have suggested that iron overload may contribute to abdominal aortic aneurysm (AAA) pathogenesis. Methods: We assessed the association of total body iron, as measured by plasma ferritin, with AAA diagnosis, size and growth in 4024 community-dwelling older men screened for AAA, using logistic regression and linear mixed effects models. Results: Plasma ferritin concentrations were similar in men who did (n = 293) and did not (n = 3731) have an AAA (median [inter-quartile range] concentrations 115.4 [63.0-203.1] and 128.5 [66.1-229.1] ng/mL respectively, p = 0.124). There was no association between plasma ferritin concentration and AAA diagnosis in unadjusted logistic regression (odds ratio (OR) for a 1 standard deviation increase: 0.880 [95%CI: 0.764-1.015]; p = 0.078), or when adjusting for AAA risk factors and factors known to influence circulating ferritin (OR for a 1 standard deviation increase: 0.898 [95% CI: 0.778-1.035]; p = 0.138). Iron overload prevalence (plasma ferritin concentrations >200 ng/mL) was lower in men with an AAA (25.3%) than those without (30.8%; p = 0.048), but was not associated with AAA diagnosis after adjusting as above (OR: 0.781 [95% CI:0.589-1.035]; p = 0.086). The association of iron overload with AAA growth was investigated in 265 men with small AAAs who received at least 1 repeat ultrasound scan in the 3 years following screening. We saw no difference in AAA growth between men who did and did not have iron overload (n = 65 and 185 respectively, p = 0.164). Conclusions: Our data suggest that iron overload is unlikely to be important in AAA pathogenesis.

    AB - © 2016. Background and aims: Experimental studies using a rodent model have suggested that iron overload may contribute to abdominal aortic aneurysm (AAA) pathogenesis. Methods: We assessed the association of total body iron, as measured by plasma ferritin, with AAA diagnosis, size and growth in 4024 community-dwelling older men screened for AAA, using logistic regression and linear mixed effects models. Results: Plasma ferritin concentrations were similar in men who did (n = 293) and did not (n = 3731) have an AAA (median [inter-quartile range] concentrations 115.4 [63.0-203.1] and 128.5 [66.1-229.1] ng/mL respectively, p = 0.124). There was no association between plasma ferritin concentration and AAA diagnosis in unadjusted logistic regression (odds ratio (OR) for a 1 standard deviation increase: 0.880 [95%CI: 0.764-1.015]; p = 0.078), or when adjusting for AAA risk factors and factors known to influence circulating ferritin (OR for a 1 standard deviation increase: 0.898 [95% CI: 0.778-1.035]; p = 0.138). Iron overload prevalence (plasma ferritin concentrations >200 ng/mL) was lower in men with an AAA (25.3%) than those without (30.8%; p = 0.048), but was not associated with AAA diagnosis after adjusting as above (OR: 0.781 [95% CI:0.589-1.035]; p = 0.086). The association of iron overload with AAA growth was investigated in 265 men with small AAAs who received at least 1 repeat ultrasound scan in the 3 years following screening. We saw no difference in AAA growth between men who did and did not have iron overload (n = 65 and 185 respectively, p = 0.164). Conclusions: Our data suggest that iron overload is unlikely to be important in AAA pathogenesis.

    U2 - 10.1016/j.atherosclerosis.2016.05.022

    DO - 10.1016/j.atherosclerosis.2016.05.022

    M3 - Article

    VL - 251

    SP - 19

    EP - 24

    JO - Atherosclerosis

    JF - Atherosclerosis

    SN - 0021-9150

    ER -