Plasma cholinesterase activity of rats, western grey kangaroos, alpacas, sheep, cattle, and horses

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    Abstract

    © 2015 Elsevier Inc. Introduction: Plasma cholinesterase activity levels of various species may be of interest to toxicologists or pathologists working with chemicals that interfere with the activity of plasma cholinesterase. Methods: We used a pH titration method to measure the plasma cholinesterase activity of six mammalian species. Results: Plasma cholinesterase activity varied up to 50-fold between species: sheep (88. ±. 45. nM acetylcholine degraded per ml of test plasma per minute), cattle (94. ±. 35), western grey kangaroos (126. ±. 92), alpaca (364. ±. 70), rats (390. ±. 118) and horses (4539. ±. 721). Discussion: We present a simple, effective technique for the assay of plasma cholinesterase activity levels from a range of species. Although labour-intensive, it requires only basic laboratory equipment.
    Original languageEnglish
    Pages (from-to)26-28
    Number of pages3
    JournalJournal of Pharmacological and Toxicological Methods
    Volume72
    Early online date15 Jan 2015
    DOIs
    Publication statusPublished - Mar 2015

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