Plasma Bioavailable Interleukin-6 Is Elevated in Human Immunodeficiency Virus-Infected Patients Who Experience Herpesvirus-Associated Immune Restoration Disease after Start of Highly Active Antiretroviral Therapy

Shelley Stone, Patricia Price, J. Brochier, Martyn French

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

This study compared plasma bioavailable interleukin (IL)-6 levels in 3 groups: human immunodeficiency virus (HIV)-infected patients who had a human herpesvirus (HHV)-associated immune restoration disease (IRD) during highly active antiretroviral therapy (HAART); patients who experienced an IRD initiated by Mycobacterium avium complex, hepatitis C virus, or human papillomavirus; and control patients who had uneventful immune reconstitution. Total IL-6, soluble IL-6 receptor (sIL-6R), and soluble gp130 were measured by ELISA, and levels of free IL-6 and sIL-6/IL-6R complex were modeled mathematically. Persons who had an HHV-associated IRD had increased plasma bioavailable IL-6 before HAART, compared with patients who experienced a non-HHV-associated IRD and with control patients, and their plasma bioavailable IL-6 increased progressively over 3-4 years of treatment. Increased IL-6 production may be a feature of HAART-induced restoration of immune responses to HHV infections and may have long-term immunopathologic consequences.
Original languageEnglish
Pages (from-to)1073-1077
JournalJournal of Infectious Diseases
Volume184
Issue number15 October
DOIs
Publication statusPublished - 2001

Fingerprint Dive into the research topics of 'Plasma Bioavailable Interleukin-6 Is Elevated in Human Immunodeficiency Virus-Infected Patients Who Experience Herpesvirus-Associated Immune Restoration Disease after Start of Highly Active Antiretroviral Therapy'. Together they form a unique fingerprint.

  • Cite this