Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence

J. Golledge, P. Clancy, J.M. Maguire, L.F. Lincz, S.A. Koblar, M.A. McEvoy, J.R. Attia, C.R. Levi, J.W. Sturm, Osvaldo Almeida, Bu Yeap, Leon Flicker, Paul Norman, Graeme J. Hankey

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Abstract

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P
Original languageEnglish
Pages (from-to)1064-1068
JournalStroke
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2014

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    Golledge, J., Clancy, P., Maguire, J. M., Lincz, L. F., Koblar, S. A., McEvoy, M. A., Attia, J. R., Levi, C. R., Sturm, J. W., Almeida, O., Yeap, B., Flicker, L., Norman, P., & Hankey, G. J. (2014). Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence. Stroke, 45(4), 1064-1068. https://doi.org/10.1161/STROKEAHA.113.004339