Some pasture species produce plant secondary compounds (PSCs) that are harmful to livestock. To screen plants for PSCs that disrupt reproduction in sheep, we used artificial reproductive technology, specifically In Vitro Maturation, Fertilization and Culture (IVMFC). We showed that this approach would work with isoflavone, a PSC known to cause infertility in sheep. We then tested extracts of several forage plants and found that Biserrula produces a PSC that might benefit reproduction rather than disrupt it. Finally, we used IVMFC to show that the beneficial PSC in Biserrula is loliolide. We now need to transfer these concepts to grazing animals.