Placental Transfer of SSRI and SNRI Antidepressants and Effects on the Neonate

Jon Rampono, Karen Simmer, K.F. Ilett, L.P. Hackett, Dorota Doherty, R. Elliot, C.H. Kok, A. Coenen, T. Forman

    Research output: Contribution to journalArticlepeer-review

    202 Citations (Scopus)


    Introduction: We investigated placental transfer and neurobehavioural effects in neonates exposed to citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline (SSRI's), or to venlafaxine (an SNRI).Methods: Women receiving antidepressants during pregnancy and their neonates were studied. Cord and maternal drug concentrations were measured at birth and in the neonates plasma on day 3. Neonates were also assessed using a range of neurobehavioral tests and compared to controls.Results: Median cord/maternal distribution ratio was 0.7-0.86 (range) for SSRIs, 0.72 for the SNRI venlafaxine and 1.08 for the O-desmethyl metabolite. Neonatal abstinence scores were significantly higher (p
    Original languageEnglish
    Pages (from-to)1-6
    Issue number3
    Publication statusPublished - 2009


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