Physiological responses of the airway wall and lung in hyperresponsive pigs

Debra Turner, P.R. Gray, S.A. Taylor, J. Thomas, Howard Mitchell

Research output: Contribution to journalArticle

5 Citations (Scopus)


Airway hyperresponsiveness (AHR) might be driven by mechanisms inherent to the airway wall, and/or by factors arising from outside the airways. A porcine model of allergen-induced AHR was utilized to investigate physiological responses in intact airways in vitro and their contribution to responsiveness in vivo.Responsiveness to acetylcholine (ACh) was measured in eight ovalbumin (OA)-sensitized/challenged pigs (tests) and eight saline-challenged controls. In vivo responsiveness to ACh was determined from pulmonary resistance (RL,). In vitro responsiveness to ACh was determined from airway pressure in isovolumic bronchial segments, after exposure via the adventitial or the luminal surface.Test pigs had lung (255 +/-26%) increase in R-L, p
Original languageEnglish
Pages (from-to)1-7
JournalEuropean Respiratory Journal
Publication statusPublished - 2001


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