Physiological Insights Into the Role of Pericytes in Spinal Cord Injury

Haiming Jin; Jessica Rawlins; Yiqi Chen; Xiaohang Zheng; Oscar Charlesworth; Junchun Chen; Gang Wang; Huoling Luo; Wenxiang Cheng; Zhong Alan Li; Sipin Zhu; Jiake Xu

doi:10.1002/jcp.31500

Physiological Insights Into the Role of Pericytes in Spinal Cord Injury

Haiming Jin, Jessica Rawlins, Yiqi Chen, Xiaohang Zheng, Oscar Charlesworth, Junchun Chen, Gang Wang, Huoling Luo, Wenxiang Cheng, Zhong Alan Li, Sipin Zhu, Jiake Xu

Research output: Contribution to journal › Review article › peer-review

Abstract

Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined with vessel-specific endothelial cells and actively contribute to maintaining the spinal cord's vascular network. Within the neurovascular unit (NVU), subtypes of pericytes characterized by various markers such as PDGFR-β, Desmin, CD146, and NG-2 are involved in vascular regeneration in SCI repair. Various pericyte signaling, pericyte-derived exosomes, and endothelial–pericyte interplay were revealed to participate in SCI repair or fibrotic scars. Through further understanding pericyte biology, it is aimed to accurately generate subtypes of pericytes and develop their therapeutic potential. This review focuses on recent advanced research and development of pericytes as a potential treatment for SCI.

Original language	English
Article number	e31500
Number of pages	9
Journal	Journal of Cellular Physiology
Volume	240
Issue number	1
DOIs	https://doi.org/10.1002/jcp.31500
Publication status	Published - Jan 2025

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title = "Physiological Insights Into the Role of Pericytes in Spinal Cord Injury",

abstract = "Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined with vessel-specific endothelial cells and actively contribute to maintaining the spinal cord's vascular network. Within the neurovascular unit (NVU), subtypes of pericytes characterized by various markers such as PDGFR-β, Desmin, CD146, and NG-2 are involved in vascular regeneration in SCI repair. Various pericyte signaling, pericyte-derived exosomes, and endothelial–pericyte interplay were revealed to participate in SCI repair or fibrotic scars. Through further understanding pericyte biology, it is aimed to accurately generate subtypes of pericytes and develop their therapeutic potential. This review focuses on recent advanced research and development of pericytes as a potential treatment for SCI.",

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AU - Jin, Haiming

AU - Rawlins, Jessica

AU - Chen, Yiqi

AU - Zheng, Xiaohang

AU - Charlesworth, Oscar

AU - Chen, Junchun

AU - Wang, Gang

AU - Luo, Huoling

AU - Cheng, Wenxiang

AU - Li, Zhong Alan

AU - Zhu, Sipin

AU - Xu, Jiake

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AB - Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined with vessel-specific endothelial cells and actively contribute to maintaining the spinal cord's vascular network. Within the neurovascular unit (NVU), subtypes of pericytes characterized by various markers such as PDGFR-β, Desmin, CD146, and NG-2 are involved in vascular regeneration in SCI repair. Various pericyte signaling, pericyte-derived exosomes, and endothelial–pericyte interplay were revealed to participate in SCI repair or fibrotic scars. Through further understanding pericyte biology, it is aimed to accurately generate subtypes of pericytes and develop their therapeutic potential. This review focuses on recent advanced research and development of pericytes as a potential treatment for SCI.

KW - pericyte

KW - physiology

KW - spinal cord injury

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Physiological Insights Into the Role of Pericytes in Spinal Cord Injury

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