TY - JOUR
T1 - Physiological functions of malate shuttles in plants and algae
AU - Dao, Ousmane
AU - Kuhnert, Franziska
AU - Weber, Andreas P.M.
AU - Peltier, Gilles
AU - Li-Beisson, Yonghua
PY - 2022/5
Y1 - 2022/5
N2 - Subcellular compartmentalization confers evolutionary advantage to eukaryotic cells but entails the need for efficient interorganelle communication. Malate functions as redox carrier and metabolic intermediate. It can be shuttled across membranes through translocators. The interconversion of malate and oxaloacetate mediated by malate dehydrogenases requires oxidation/reduction of NAD(P)H/NAD(P)+; therefore, malate trafficking serves to transport reducing equivalents and this is termed the ‘malate shuttle’. Although the term 'malate shuttle' was coined more than 50 years ago, novel functions are still emerging. This review highlights recent findings on the functions of malate shuttles in photorespiration, fatty acid β-oxidation, interorganelle signaling and its putative role in CO2-concentrating mechanisms. We compare and contrast knowledge in plants and algae, thereby providing an evolutionary perspective on redox trafficking in photosynthetic eukaryotes.
AB - Subcellular compartmentalization confers evolutionary advantage to eukaryotic cells but entails the need for efficient interorganelle communication. Malate functions as redox carrier and metabolic intermediate. It can be shuttled across membranes through translocators. The interconversion of malate and oxaloacetate mediated by malate dehydrogenases requires oxidation/reduction of NAD(P)H/NAD(P)+; therefore, malate trafficking serves to transport reducing equivalents and this is termed the ‘malate shuttle’. Although the term 'malate shuttle' was coined more than 50 years ago, novel functions are still emerging. This review highlights recent findings on the functions of malate shuttles in photorespiration, fatty acid β-oxidation, interorganelle signaling and its putative role in CO2-concentrating mechanisms. We compare and contrast knowledge in plants and algae, thereby providing an evolutionary perspective on redox trafficking in photosynthetic eukaryotes.
KW - CO concentrating mechanism
KW - dicarboxylate translocator
KW - malate dehydrogenase
KW - photorespiration
KW - reactive oxygen species
KW - redox trafficking
UR - http://www.scopus.com/inward/record.url?scp=85120166767&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2021.11.007
DO - 10.1016/j.tplants.2021.11.007
M3 - Review article
C2 - 34848143
AN - SCOPUS:85120166767
SN - 1360-1385
VL - 27
SP - 488
EP - 501
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 5
ER -