Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Belinda Brown; J.J. Peiffer; K. Taddei; J.K. Lui; S.M. Laws; V.B. Gupta; T. Taddei; Vanessa Ward; M.A. Rodrigues; S.C. Burnham; S.R. Rainey-Smith; V.L. Villemagne; A.I. Bush; K.A. Ellis; C.L. Masters; D.J. Ames; S.L. Macaulay; C.E.I. Szoeke; C.C. Rowe; Ralph Martins

doi:10.1038/mp.2012.107

Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Belinda Brown, J.J. Peiffer, K. Taddei, J.K. Lui, S.M. Laws, V.B. Gupta, T. Taddei, Vanessa Ward, M.A. Rodrigues, S.C. Burnham, S.R. Rainey-Smith, V.L. Villemagne, A.I. Bush, K.A. Ellis, C.L. Masters, D.J. Ames, S.L. Macaulay, C.E.I. Szoeke, C.C. Rowe, Ralph Martins

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Abstract

Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-β (Aβ) and Aβ brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Aβ and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) ε4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma Aβ levels were measured in fasting blood samples. A subgroup (n=116) underwent 11 C-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load. Higher levels of physical activity were associated with higher high density lipoprotein (HDL) (P=0.037), and lower insulin (P

Original language	English
Pages (from-to)	875-881
Journal	Molecular Psychiatry
Volume	18
Issue number	8
DOIs	https://doi.org/10.1038/mp.2012.107
Publication status	Published - 2013

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Brown, B., Peiffer, J. J., Taddei, K., Lui, J. K., Laws, S. M., Gupta, V. B., Taddei, T., Ward, V., Rodrigues, M. A., Burnham, S. C., Rainey-Smith, S. R., Villemagne, V. L., Bush, A. I., Ellis, K. A., Masters, C. L., Ames, D. J., Macaulay, S. L., Szoeke, C. E. I., Rowe, C. C., & Martins, R. (2013). Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881. https://doi.org/10.1038/mp.2012.107

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title = "Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing",

abstract = "Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-β (Aβ) and Aβ brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Aβ and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) ε4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma Aβ levels were measured in fasting blood samples. A subgroup (n=116) underwent 11 C-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load. Higher levels of physical activity were associated with higher high density lipoprotein (HDL) (P=0.037), and lower insulin (P",

author = "Belinda Brown and J.J. Peiffer and K. Taddei and J.K. Lui and S.M. Laws and V.B. Gupta and T. Taddei and Vanessa Ward and M.A. Rodrigues and S.C. Burnham and S.R. Rainey-Smith and V.L. Villemagne and A.I. Bush and K.A. Ellis and C.L. Masters and D.J. Ames and S.L. Macaulay and C.E.I. Szoeke and C.C. Rowe and Ralph Martins",

year = "2013",

doi = "10.1038/mp.2012.107",

language = "English",

volume = "18",

pages = "875--881",

journal = "Molecular Psychiatry",

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Brown, B, Peiffer, JJ, Taddei, K, Lui, JK, Laws, SM, Gupta, VB, Taddei, T, Ward, V, Rodrigues, MA, Burnham, SC, Rainey-Smith, SR, Villemagne, VL, Bush, AI, Ellis, KA, Masters, CL, Ames, DJ, Macaulay, SL, Szoeke, CEI, Rowe, CC & Martins, R 2013, 'Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing', Molecular Psychiatry, vol. 18, no. 8, pp. 875-881. https://doi.org/10.1038/mp.2012.107

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T1 - Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

AU - Brown, Belinda

AU - Peiffer, J.J.

AU - Taddei, K.

AU - Lui, J.K.

AU - Laws, S.M.

AU - Gupta, V.B.

AU - Taddei, T.

AU - Ward, Vanessa

AU - Rodrigues, M.A.

AU - Burnham, S.C.

AU - Rainey-Smith, S.R.

AU - Villemagne, V.L.

AU - Bush, A.I.

AU - Ellis, K.A.

AU - Masters, C.L.

AU - Ames, D.J.

AU - Macaulay, S.L.

AU - Szoeke, C.E.I.

AU - Rowe, C.C.

AU - Martins, Ralph

PY - 2013

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N2 - Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-β (Aβ) and Aβ brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Aβ and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) ε4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma Aβ levels were measured in fasting blood samples. A subgroup (n=116) underwent 11 C-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load. Higher levels of physical activity were associated with higher high density lipoprotein (HDL) (P=0.037), and lower insulin (P

AB - Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-β (Aβ) and Aβ brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Aβ and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) ε4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma Aβ levels were measured in fasting blood samples. A subgroup (n=116) underwent 11 C-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load. Higher levels of physical activity were associated with higher high density lipoprotein (HDL) (P=0.037), and lower insulin (P

U2 - 10.1038/mp.2012.107

DO - 10.1038/mp.2012.107

M3 - Article

SN - 1359-4184

VL - 18

SP - 875

EP - 881

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 8

ER -

Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Abstract

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