TY - JOUR
T1 - Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4
AU - Cattley, S.K.
AU - Longman, N.
AU - Dawkins, R.L.
AU - Gaudieri, Silvana
AU - Kulski, J.K.
AU - Leelayuwat, C.
PY - 1999
Y1 - 1999
N2 - Duplication of segments within the MHC has led to numerous multicopy families such as class I, class II, C4 and MIC (PERB11). Different copy numbers between haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee.By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5 rather than MICA. (PERB11.1). These findings indicate that the primate MHC is more plastic than has been appreciated.
AB - Duplication of segments within the MHC has led to numerous multicopy families such as class I, class II, C4 and MIC (PERB11). Different copy numbers between haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee.By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5 rather than MICA. (PERB11.1). These findings indicate that the primate MHC is more plastic than has been appreciated.
U2 - 10.1046/j.1365-2370.1999.00154.x
DO - 10.1046/j.1365-2370.1999.00154.x
M3 - Article
VL - 26
SP - 233
EP - 238
JO - European Journal of Immunogenetics
JF - European Journal of Immunogenetics
SN - 0960-7420
IS - 2-3
ER -