Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4

S.K. Cattley; N. Longman; R.L. Dawkins; Silvana Gaudieri; J.K. Kulski; C. Leelayuwat

doi:10.1046/j.1365-2370.1999.00154.x

Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4

S.K. Cattley, N. Longman, R.L. Dawkins, Silvana Gaudieri, J.K. Kulski, C. Leelayuwat

Graduate Research School

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

Duplication of segments within the MHC has led to numerous multicopy families such as class I, class II, C4 and MIC (PERB11). Different copy numbers between haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee.By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5 rather than MICA. (PERB11.1). These findings indicate that the primate MHC is more plastic than has been appreciated.

Original language	English
Pages (from-to)	233-238
Journal	European Journal of Immunogenetics
Volume	26
Issue number	2-3
DOIs	https://doi.org/10.1046/j.1365-2370.1999.00154.x
Publication status	Published - 1999

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Cattley, S. K., Longman, N., Dawkins, R. L., Gaudieri, S., Kulski, J. K., & Leelayuwat, C. (1999). Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4. European Journal of Immunogenetics, 26(2-3), 233-238. https://doi.org/10.1046/j.1365-2370.1999.00154.x

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title = "Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4",

abstract = "Duplication of segments within the MHC has led to numerous multicopy families such as class I, class II, C4 and MIC (PERB11). Different copy numbers between haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee.By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5 rather than MICA. (PERB11.1). These findings indicate that the primate MHC is more plastic than has been appreciated.",

author = "S.K. Cattley and N. Longman and R.L. Dawkins and Silvana Gaudieri and J.K. Kulski and C. Leelayuwat",

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doi = "10.1046/j.1365-2370.1999.00154.x",

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Cattley, SK, Longman, N, Dawkins, RL, Gaudieri, S , Kulski, JK & Leelayuwat, C 1999, 'Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4', European Journal of Immunogenetics, vol. 26, no. 2-3, pp. 233-238. https://doi.org/10.1046/j.1365-2370.1999.00154.x

Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4. / Cattley, S.K.; Longman, N.; Dawkins, R.L.; Gaudieri, Silvana ; Kulski, J.K.; Leelayuwat, C.

In: European Journal of Immunogenetics, Vol. 26, No. 2-3, 1999, p. 233-238.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4

AU - Cattley, S.K.

AU - Longman, N.

AU - Dawkins, R.L.

AU - Gaudieri, Silvana

AU - Kulski, J.K.

AU - Leelayuwat, C.

PY - 1999

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AB - Duplication of segments within the MHC has led to numerous multicopy families such as class I, class II, C4 and MIC (PERB11). Different copy numbers between haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee.By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5 rather than MICA. (PERB11.1). These findings indicate that the primate MHC is more plastic than has been appreciated.

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DO - 10.1046/j.1365-2370.1999.00154.x

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