Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation

P. H. Hart; J. J. Finlay-Jones; S. Gorman

doi:10.1007/978-3-540-35989-0_12

Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation

P. H. Hart, J. J. Finlay-Jones, S. Gorman

Research output: Chapter in Book/Conference paper › Chapter › peer-review

2 Citations (Scopus)

Abstract

UVR component of sunlight is immunomodulatory with suppression of cellular immunity to antigens applied at both irradiated and non-irradiated sites. Via isomerization of trans-urocanic acid in the stratum corneum to its more soluble cis isomer, UVR activates peripheral sensory nerves for release of calcitonin gene-related protein and substance P. Dermal mast cells activated by neuropeptides contribute to the immunomodulatory properties of UV. UVR-induced keratinocyte nerve growth factor production augments activation of peripheral sensory nerves for neuropeptide release. UVR-induced keratinocyte α-melanocyte stimulating hormone is immunosuppressive by stimulating keratinocyte IL-10 production, as well as increasing melanogenesis and repair of UV-induced DNA damage in melanocytes and keratinocytes. There is debate upon whether UVA wavelengths (400-320nm) have immunosuppressive properties similar to those of UVB (320-290nm).

Original language	English
Title of host publication	Neuroimmunology of the Skin
Subtitle of host publication	Basic Science to Clinical Practice
Publisher	Springer, Berlin, Heidelberg
Pages	125-136
Number of pages	12
ISBN (Print)	9783540359869
DOIs	https://doi.org/10.1007/978-3-540-35989-0_12
Publication status	Published - 1 Dec 2009
Externally published	Yes

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10.1007/978-3-540-35989-0_12

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abstract = "UVR component of sunlight is immunomodulatory with suppression of cellular immunity to antigens applied at both irradiated and non-irradiated sites. Via isomerization of trans-urocanic acid in the stratum corneum to its more soluble cis isomer, UVR activates peripheral sensory nerves for release of calcitonin gene-related protein and substance P. Dermal mast cells activated by neuropeptides contribute to the immunomodulatory properties of UV. UVR-induced keratinocyte nerve growth factor production augments activation of peripheral sensory nerves for neuropeptide release. UVR-induced keratinocyte α-melanocyte stimulating hormone is immunosuppressive by stimulating keratinocyte IL-10 production, as well as increasing melanogenesis and repair of UV-induced DNA damage in melanocytes and keratinocytes. There is debate upon whether UVA wavelengths (400-320nm) have immunosuppressive properties similar to those of UVB (320-290nm).",

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AU - Gorman, S.

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Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation

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