Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation

P. H. Hart, J. J. Finlay-Jones, S. Gorman

Research output: Chapter in Book/Conference paperChapter

1 Citation (Scopus)

Abstract

UVR component of sunlight is immunomodulatory with suppression of cellular immunity to antigens applied at both irradiated and non-irradiated sites. Via isomerization of trans-urocanic acid in the stratum corneum to its more soluble cis isomer, UVR activates peripheral sensory nerves for release of calcitonin gene-related protein and substance P. Dermal mast cells activated by neuropeptides contribute to the immunomodulatory properties of UV. UVR-induced keratinocyte nerve growth factor production augments activation of peripheral sensory nerves for neuropeptide release. UVR-induced keratinocyte α-melanocyte stimulating hormone is immunosuppressive by stimulating keratinocyte IL-10 production, as well as increasing melanogenesis and repair of UV-induced DNA damage in melanocytes and keratinocytes. There is debate upon whether UVA wavelengths (400-320nm) have immunosuppressive properties similar to those of UVB (320-290nm).

Original languageEnglish
Title of host publicationNeuroimmunology of the Skin
Subtitle of host publicationBasic Science to Clinical Practice
PublisherSpringer, Berlin, Heidelberg
Pages125-136
Number of pages12
ISBN (Print)9783540359869
DOIs
Publication statusPublished - 1 Dec 2009

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Keratinocytes
Radiation
Immunosuppressive Agents
Neuropeptides
Peripheral Nerves
Urocanic Acid
Melanocyte-Stimulating Hormones
Sunlight
Melanocytes
Calcitonin
Nerve Growth Factor
Substance P
Mast Cells
Cellular Immunity
Interleukin-10
Cornea
DNA Damage
Antigens
Skin
Proteins

Cite this

Hart, P. H., Finlay-Jones, J. J., & Gorman, S. (2009). Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation. In Neuroimmunology of the Skin: Basic Science to Clinical Practice (pp. 125-136). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_12
Hart, P. H. ; Finlay-Jones, J. J. ; Gorman, S. / Photoneuroimmunology : Modulation of the neuroimmune system by UV radiation. Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer, Berlin, Heidelberg, 2009. pp. 125-136
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Hart, PH, Finlay-Jones, JJ & Gorman, S 2009, Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation. in Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer, Berlin, Heidelberg, pp. 125-136. https://doi.org/10.1007/978-3-540-35989-0_12

Photoneuroimmunology : Modulation of the neuroimmune system by UV radiation. / Hart, P. H.; Finlay-Jones, J. J.; Gorman, S.

Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer, Berlin, Heidelberg, 2009. p. 125-136.

Research output: Chapter in Book/Conference paperChapter

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Hart PH, Finlay-Jones JJ, Gorman S. Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation. In Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer, Berlin, Heidelberg. 2009. p. 125-136 https://doi.org/10.1007/978-3-540-35989-0_12