Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation

P. H. Hart, J. J. Finlay-Jones, S. Gorman

Research output: Chapter in Book/Conference paperChapterpeer-review

2 Citations (Scopus)


UVR component of sunlight is immunomodulatory with suppression of cellular immunity to antigens applied at both irradiated and non-irradiated sites. Via isomerization of trans-urocanic acid in the stratum corneum to its more soluble cis isomer, UVR activates peripheral sensory nerves for release of calcitonin gene-related protein and substance P. Dermal mast cells activated by neuropeptides contribute to the immunomodulatory properties of UV. UVR-induced keratinocyte nerve growth factor production augments activation of peripheral sensory nerves for neuropeptide release. UVR-induced keratinocyte α-melanocyte stimulating hormone is immunosuppressive by stimulating keratinocyte IL-10 production, as well as increasing melanogenesis and repair of UV-induced DNA damage in melanocytes and keratinocytes. There is debate upon whether UVA wavelengths (400-320nm) have immunosuppressive properties similar to those of UVB (320-290nm).

Original languageEnglish
Title of host publicationNeuroimmunology of the Skin
Subtitle of host publicationBasic Science to Clinical Practice
PublisherSpringer, Berlin, Heidelberg
Number of pages12
ISBN (Print)9783540359869
Publication statusPublished - 1 Dec 2009
Externally publishedYes


Dive into the research topics of 'Photoneuroimmunology: Modulation of the neuroimmune system by UV radiation'. Together they form a unique fingerprint.

Cite this