Abstract
The toxicities and phototoxicities of methylene blue and its two methylated derivatives were measured against one standard and three vancomycin-resistant pathogenic strains of Enterococcus spp. Each of the compounds was bactericidal and the derivatives exhibited photobactericidal activity on illumination at a 'light' dose of 6.3 J/cm2 against one or more of the strains. Increased bactericidal and photobactericidal activity in the methylated derivatives is thought to be due to their higher hydrophobicities allowing greater interaction with the bacterial cell wall. In addition, the derivatives exhibited higher inherent photosensitizing efficacies.
| Original language | English |
|---|---|
| Pages (from-to) | 823-825 |
| Number of pages | 3 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1999 |
| Externally published | Yes |
