Pharmscogenetic characteristics of substance abuse patients who are receiving therapy for their addiction

Laith Al-Eitan

    Research output: ThesisDoctoral Thesis

    1172 Downloads (Pure)

    Abstract

    [Truncated abstract] This project- 7 studies was first proposed in 2009 with the aim of identifying genetic markers within selected candidate genes that may influence susceptibility to substance dependence and treatment response. To achieve this aim, a comparative study of substance dependent patients and individuals with no lifetime history of substance abuse was planned. Samples were obtained from consenting volunteers from a Jordanian population of Arab descent and phenotypic and genotypic data were systematically compiled in a database for study purposes. Prior to this project, clinical, epidemiological and pharmacogenetic characteristics of substance dependent patients of Arab descent had not yet been described. Significant advances in DNA technology, particularly in the field of DNA arrays, provide the opportunity to study this population for the first time. Collection of the data for this study was made possible through the collaboration of four institutions: The National Centre for Rehabilitation of Addicts (NCRA) at The Jordanian Ministry of Health, the Drug Rehabilitation Centre at The Jordanian Public Security Directorate, Jordan University of Science and Technology and The University of Western Australia. Through assistance from the Jordanian Ministry of Health and collaborators of this network, demographic and clinical data of substance dependent patients (N = 220) were collected and collated in a database for analysis. Clinical specimens were also collected for genetic association and pharmacogenetic studies. In addition, 240 healthy males from an ethnically homogenous Jordanian Arab population with no lifetime history of psychosis or mood disorders, or substance dependence according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria were used as controls. Written informed consent was obtained from all subjects (N = 460) included in the study.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Publication statusUnpublished - 2012

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