Pharmacokinetics of Nasal Fentanyl

S. Lim, Mike Paech, V.B. Sunderland, M.J. Roberts, S.L. Banks, M.W.M. Rucklidge

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To investigate the pharmacokinetics of intranasal fentanyl in adult postoperative female patients. Method: Patients received both intravenous and intranasal fentanyl (approximately 50 micrograms) in a randomised cross over study. Results: Pharmacokinetic data sets from 19 patients showed intranasal fentanyl produced plasma levels within the therapeutic range within two minutes, with median bioavailability values of 55% (pH 6 formulation) and 71% (pH 8 formulation). Mean peak serum concentrations were 0.33 ng/mL (pH 6) and 0.37 ng/mL (pH 8) respectively, compared with 2.33 ng/mL after intravenous fentanyl. Conclusion: We conclude that the absorption of intranasal fentanyl is rapid, the bioavailability more than half that of intravenous administration and that the formulations studied are suitable for more extensive clinical evaluation.
Original languageEnglish
Pages (from-to)59-63
JournalJournal of Pharmacy Practice and Research
Volume33
Issue number1
Publication statusPublished - 2003

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