Pharmacokinetics of Nasal Fentanyl

S. Lim, Mike Paech, V.B. Sunderland, M.J. Roberts, S.L. Banks, M.W.M. Rucklidge

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    45 Citations (Scopus)

    Abstract

    Objective: To investigate the pharmacokinetics of intranasal fentanyl in adult postoperative female patients. Method: Patients received both intravenous and intranasal fentanyl (approximately 50 micrograms) in a randomised cross over study. Results: Pharmacokinetic data sets from 19 patients showed intranasal fentanyl produced plasma levels within the therapeutic range within two minutes, with median bioavailability values of 55% (pH 6 formulation) and 71% (pH 8 formulation). Mean peak serum concentrations were 0.33 ng/mL (pH 6) and 0.37 ng/mL (pH 8) respectively, compared with 2.33 ng/mL after intravenous fentanyl. Conclusion: We conclude that the absorption of intranasal fentanyl is rapid, the bioavailability more than half that of intravenous administration and that the formulations studied are suitable for more extensive clinical evaluation.
    Original languageEnglish
    Pages (from-to)59-63
    JournalJournal of Pharmacy Practice and Research
    Volume33
    Issue number1
    Publication statusPublished - 2003

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