Pharmacokinetics and Bioavailability of Hydromorphone Nasal Spray

S.C.B. Lim, Mike Paech, R. Goy, Y. Liu, G. Zhang, M. Yao, Dorota Doherty

Research output: Contribution to journalArticle

2 Citations (Scopus)


Aim: To evaluate the pharmacokinetics and bioavailability of two formulations of intranasal hydromorphone hydrochloride in adult postoperative patients. Method: In an open-label, randomised, crossover study a convenience sample of adult postoperative patients received intravenous hydromorphone 1 mg and intranasal hydromorphone 2 mg (with and without chitosan). Results: Pharmacokinetic data sets from 19 patients showed intranasal hydromorphone produced detectable serum levels within 2 minutes of administration, with mean bioavailability of 49.5% (without chitosan) and 67.5% (with chitosan). Mean peak serum concentrations were 0.92 ng/mL (without chitosan) and 1.16 ng/mL (with chitosan). Summed pain intensity differences suggest that intravenous hydromorphone produced a better clinical response. Conclusion: The bioavailability of intranasal hydromorphone is approximately 0.6 of intravenous hydromorphone. Adding chitosan to the intranasal solution did not significantly increase the bioavailability of hydromorphone.
Original languageEnglish
Pages (from-to)191-195
JournalJournal of Pharmacy Practice and Research
Issue number3
Publication statusPublished - 2008

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