Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity

A.M. Martin, D. Nolan, Silvana Gaudieri, E. Phillips, S. Mallal

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    The application of a pharmacogenetic approach to antiretroviral drug therapy represents a significant challenge, as treatment involves multiple drugs and drug classes with the potential for significant variability in drug-host, as well as drug-drug, interactions. However, despite this inherent complexity, considerable gains have been made in understanding how genetic factors influence the efficacy and toxicity of HIV therapy. In this review the available evidence regarding genetic variation in drug disposition will be examined, including the potential for relatively polymorphic drug-metabolizing enzymes (e.g., cytochrome P450 isoforms) and drug transporters (e.g., P-glycoprotein) to influence the disposition of HIV protease inhibitor and non-nucleoside reverse transcriptase inhibitor drugs. In addition, the role of genetic variation in determining the immune response to drug-specific antigens will be considered as a potentially significant determinant of susceptibility to idiosyncratic drug reactions (e.g., major histocompatibility complex alleles associated with abacavir hypersensitivity). The current and potential clinical utility of pharmacogenetic testing in HIV management will also be emphasized.
    Original languageEnglish
    Pages (from-to)643-655
    JournalPharmacogenomics
    Volume5
    Issue number6
    DOIs
    Publication statusPublished - 2004

      Fingerprint

    Cite this