Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review

Rachael C. Heath Jeffery, Fred K. Chen

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a laterally bulging herniation of distended axons into the peripapillary region above the level of Bruch's membrane opening. Increased use of enhanced depth imaging-optical coherence tomography (EDI-OCT) in our evaluation of the optic nerve head (ONH) and greater recognition of the vast range of optic nerve pathologies with which PHOMS is associated provides convincing evidence that PHOMS is not just buried optic disc drusen (ODD) as previously described. The frequent coexistence of PHOMS with ODD, papilloedema, anterior ischaemic optic neuropathy, tilted optic disc syndrome, inflammatory demyelinating disorders and other diseases associated with axoplasmic stasis provides insight into its underlying pathophysiology. The present review will discuss the role of key imaging modalities in the differential diagnosis of PHOMS, explore the current literature on the relationship between PHOMS and common neuro-ophthalmic conditions, and highlight the gaps in our knowledge, with respect to disease classification and prognosis, to pave the way for future directions of research.

Original languageEnglish
Pages (from-to)67-80
Number of pages14
JournalClinical and Experimental Ophthalmology
Volume51
Issue number1
Early online date27 Oct 2022
DOIs
Publication statusPublished - 1 Jan 2023

Fingerprint

Dive into the research topics of 'Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review'. Together they form a unique fingerprint.

Cite this