Performance of Medtronic Hybrid Closed-Loop Iterations, Results from a Randomized Trial in Adolescents with Type 1 Diabetes

Martin de Bock, Julie Dart, Michael Hancock, Grant Smith, Elizabeth A. Davis, Timothy W. Jones

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7 Citations (Scopus)


This study investigates the performance of an iteration of the Medtronic hybrid closed-loop (HCL) algorithm, which utilizes sensor glucose values non-adjunctively for bolus advice, recognizes sustained hyperglycemia, suggests insulin bolus correction, and includes more accommodative SmartGuard automode parameters that aim to improve function and usability. Adolescents aged 13-17 years with type 1 diabetes >1 year, glycated hemoglobin (HbA(1c)) 7.0%-10%, currently using Continuous Subcutaneous Insulin Infusion were randomized to the control Medtronic standard HCL algorithm or to the intervention Medtronic HCL with enhancements. Participants attended a 7-day and 7-night nonstructured camp setting. Twelve participants (mean age 15 years, seven males, five females, mean HbA(1c) 8.55%) completed the study. For the control group, time in target glucose sensor range (3.9-10mmol/L) was 63.68%+/- 10.74% at baseline and changed to 75.85%+/- 8.49% during the study (relative 19%). Time spent in

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalDiabetes Technology & Therapeutics
Issue number10
Publication statusPublished - 11 Sep 2018

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