People With COPD Who Respond to Ground-Based Walking Training Are Characterized by Lower Pre-training Exercise Capacity and Better Lung Function and Have Greater Progression in Walking Training Distance

Jian Ping Ho, Jennifer A. Alison, L. W. Cindy Ng, Sally L. Wootton, Zoe J. McKeough, Sue C. Jenkins, Peter R. Eastwood, David R. Hillman, Christine Jenkins, Lissa M. Spencer, Vinicius Cavalheri, Kylie Hill

Research output: Contribution to journalArticle


Purpose: To investigate the characteristics that distinguish responders from nonresponders to ground-based walking training (GBWT) in people with chronic obstructive pulmonary disease (COPD). Methods: An analysis was undertaken of data collected during a trial of GBWT in people with COPD. Responders to GBWT were defined in 2 ways: (1) improved time on the endurance shuttle walk test of >= 190 sec (criterion A); or (2) improved ability to walk, perceived by the participant to be at least "moderate" (criterion B). Differences in participant characteristics, pre-training exercise capacity, health-related quality of life, and the improvement in the distance walked during the training program were examined between responders and nonresponders. Results: Of the 95 participants randomized to GBWT (age 69 +/- 8 yr, forced expiratory volume in 1 sec [FEV1] % predicted = 43% +/- 15%), data were available for analysis on 78 and 73 patients by criterion A and criterion B, respectively. According to criterion A, 32 (41%) participants were responders. The odds of being a responder increased with increasing FEV1 % predicted (OR = 1.2; 95% CI, 1.0-1.5, for every 5% increase) and increased with decreasing pre-training incremental shuttle walk distance (OR = 1.4; 95% CI, 1.0-1.8, for every 50-m decrement). According to criterion B, 42 (58%) participants were responders. There were no differences in characteristics or pre-training measures between the responders and nonresponders. For both criteria, responders demonstrated greater change in the distance walked during the training program (P <.05). Conclusion: Responders to GBWT had lower pre-training exercise capacity, had better lung function, and demonstrated greater change in the distance walked during the training program.

Original languageEnglish
Pages (from-to)338-343
Number of pages6
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Issue number5
Publication statusPublished - Sep 2019

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