Pentatricopeptide repeat proteins in plants

Alice Barkan, Ian Small

Research output: Contribution to journalReview article

343 Citations (Scopus)

Abstract

Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets. Copyright © 2014 by Annual Reviews.
Original languageEnglish
Pages (from-to)415-442
JournalAnnual Review of Plant Biology
Volume65
DOIs
Publication statusPublished - Apr 2014

Fingerprint

Plant Proteins
plant proteins
Proteins
Plant Development
proteins
plant development
Embryophyta
synthetic proteins
nucleotide sequences
RNA-binding proteins
RNA-Binding Proteins
embryophytes
Photosynthesis
Organelle Biogenesis
Chloroplasts
cell respiration
Growth and Development
translation (genetics)
organelles
binding sites

Cite this

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title = "Pentatricopeptide repeat proteins in plants",
abstract = "Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets. Copyright {\circledC} 2014 by Annual Reviews.",
author = "Alice Barkan and Ian Small",
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doi = "10.1146/annurev-arplant-050213-040159",
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journal = "ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY",
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Pentatricopeptide repeat proteins in plants. / Barkan, Alice; Small, Ian.

In: Annual Review of Plant Biology, Vol. 65, 04.2014, p. 415-442.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Pentatricopeptide repeat proteins in plants

AU - Barkan, Alice

AU - Small, Ian

PY - 2014/4

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N2 - Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets. Copyright © 2014 by Annual Reviews.

AB - Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants, with more than 400 members in most species. Over the past decade, much has been learned about the molecular functions of these proteins, where they act in the cell, and what physiological roles they play during plant growth and development. A typical PPR protein is targeted to mitochondria or chloroplasts, binds one or several organellar transcripts, and influences their expression by altering RNA sequence, turnover, processing, or translation. Their combined action has profound effects on organelle biogenesis and function and, consequently, on photosynthesis, respiration, plant development, and environmental responses. Recent breakthroughs in understanding how PPR proteins recognize RNA sequences through modular base-specific contacts will help match proteins to potential binding sites and provide a pathway toward designing synthetic RNA-binding proteins aimed at desired targets. Copyright © 2014 by Annual Reviews.

U2 - 10.1146/annurev-arplant-050213-040159

DO - 10.1146/annurev-arplant-050213-040159

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JO - ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY

JF - ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY

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