Penetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intravenous Artesunate in Severe Falciparum Malaria

Timothy Davis, T.Q. Binh, Kenneth Ilett, K.T. Batty, H.L. Phuong, G.M. Chiswell, V.D.B. Phuong, C. Agus

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42 Citations (Scopus)

Abstract

Penetration of cerebrospinal fluid (CSF) by artesunate and DHA was assessed in six adults with cerebral or severe malaria. Lumbar punctures were performed on admission and during convalescence, at 15 min (patient 1), 30 min (patient 2), 45 min (patient 3), 60 min (patient 4), 90 min (patient 5), and 120 min (patient 6) after intravenous administration of 120 mg of artesunate. No artesunate was detectable in CSF. In both studies, DHA levels in CSF increased with time while dihydroartemisinin levels in plasma fell. Dihydroartemisinin might accumulate in CSF during frequent artesunate dosing.
Original languageEnglish
Pages (from-to)368-370
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number1
DOIs
Publication statusPublished - 2003

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