PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

NM Smith; Colin Raston; CB Smith; AN Sobolev

doi:10.1039/b700893g

PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

NM Smith, Colin Raston, CB Smith, AN Sobolev

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen -Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

Original language	English
Pages (from-to)	1185-1190
Number of pages	1190
Journal	Green Chemistry
Volume	9
Issue number	11
DOIs	https://doi.org/10.1039/b700893g https://doi.org/10.1039/b700893g
Publication status	Published - 2007

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title = "PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines",

abstract = "The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen -Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.",

author = "NM Smith and Colin Raston and CB Smith and AN Sobolev",

year = "2007",

doi = "10.1039/b700893g",

language = "English",

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journal = "Green Chemistry",

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T1 - PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

AU - Smith, NM

AU - Raston, Colin

AU - Smith, CB

AU - Sobolev, AN

PY - 2007

Y1 - 2007

N2 - The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen -Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

AB - The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen -Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

U2 - 10.1039/b700893g

DO - 10.1039/b700893g

M3 - Article

SN - 1463-9262

VL - 9

SP - 1185

EP - 1190

JO - Green Chemistry

JF - Green Chemistry

IS - 11

ER -

PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

Abstract

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