PEDF-induced alteration of metabolism leading to insulin resistance

Revathy Carnagarin; Arunasalam M. Dharmarajan; Crispin R. Dass

doi:10.1016/j.mce.2014.11.006

PEDF-induced alteration of metabolism leading to insulin resistance

Revathy Carnagarin, Arunasalam M. Dharmarajan, Crispin R. Dass

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance.

Original language	English
Pages (from-to)	98-104
Number of pages	7
Journal	Molecular and Cellular Endocrinology
Volume	401
DOIs	https://doi.org/10.1016/j.mce.2014.11.006
Publication status	Published - 5 Feb 2015
Externally published	Yes

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10.1016/j.mce.2014.11.006

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title = "PEDF-induced alteration of metabolism leading to insulin resistance",

abstract = "Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance.",

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author = "Revathy Carnagarin and Dharmarajan, {Arunasalam M.} and Dass, {Crispin R.}",

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T1 - PEDF-induced alteration of metabolism leading to insulin resistance

AU - Carnagarin, Revathy

AU - Dharmarajan, Arunasalam M.

AU - Dass, Crispin R.

PY - 2015/2/5

Y1 - 2015/2/5

N2 - Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance.

AB - Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance.

KW - Diabetes

KW - Insulin

KW - Metabolism

KW - Obesity

KW - PEDF

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U2 - 10.1016/j.mce.2014.11.006

DO - 10.1016/j.mce.2014.11.006

M3 - Review article

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SN - 0303-7207

VL - 401

SP - 98

EP - 104

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

PEDF-induced alteration of metabolism leading to insulin resistance

Abstract

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