PAX6 expression may be protective against dopaminergic cell loss in Parkinson's Disease

Meghan Thomas, C Welch, Leah Stone, P Allan, RA Barker, Robert White

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    The transcription factor Pax6 is a well-accepted neurogenic determinant during development, in adult neural progenitor cells and in acute brain injury models. In the adult brain Pax6 is expressed in selective populations of dopaminergic neurons, and thus may have a role to play in Parkinson’s disease (PD). This study looked at post-mortem tissue from patients with PD and in particular the substantia nigra which showed a reduced number of PAX6+ cells compared to age and sex matched control tissue. In an animal model of PD, there was an early transient increase in the number of SN Pax6+ cells at the time of cell loss through apoptosis. Finally we showed that an over-expression of Pax6 in SH-SY5Y cells treated with PD relevant neurotoxins, resulted in an increase in cell survival and a reduction in markers of apoptosis and oxidative stress. These results suggest that Pax6 may have a role to play in the loss of dopaminergic neurons in PD.
    Original languageEnglish
    Pages (from-to)73-79
    JournalCNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2016

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