Patient-reported outcome measures for paediatric acute lower respiratory infection studies

Daniel B. Oakes, Megan J. Baker, Charlie McLeod, Barbara Nattabi, Christopher C. Blyth

Research output: Contribution to journalReview articlepeer-review


Background Patient-reported outcome measures (PROMs) are recommended for capturing meaningful outcomes in clinical trials. The use of PROMs for children with acute lower respiratory infections (ALRIs) has not been systematically reported. We aimed to identify and characterise patient-reported outcomes and PROMs used in paediatric ALRI studies and summarise their measurement properties. Methods Medline, Embase and Cochrane were searched (until April 2022). Studies that reported on patient-reported outcome (or measure) use or development and included subjects aged <18 years with ALRIs were included. Study, population and patient-reported outcome (or measure) characteristics were extracted. Results Of 2793 articles identified, 18 met inclusion criteria, including 12 PROMs. Two disease-specific PROMs were used in settings in which they had been validated. The Canadian Acute Respiratory Illness and Flu Scale was the most frequently used disease-specific PROM ( five studies). The EuroQol-Five Dimensions-Youth system was the most frequently used generic PROM (two studies). There was considerable heterogeneity in validation methods. The outcome measures identified in this review lack validation for young children and none involve sufficient content validity for use with First Nations children. Conclusions There is an urgent need for PROM development that considers the populations in which the burden of ALRI predominates.

Original languageEnglish
Article number220229
JournalEuropean Respiratory Review
Issue number167
Publication statusPublished - 1 Mar 2023


Dive into the research topics of 'Patient-reported outcome measures for paediatric acute lower respiratory infection studies'. Together they form a unique fingerprint.

Cite this