Projects per year
Abstract
Objective TARGIT-A randomised women with early breast cancer to receive external beam radiotherapy (EBRT) or intraoperative radiotherapy (TARGIT-IORT). This study aimed to identify what extra risk of recurrence patients would accept for perceived benefits and risks of different radiotherapy treatments. Methods Patient preferences were determined by self-rated trade-off questionnaires in two studies: Stage (1) 209 TARGIT-A participants (TARGIT-IORTn = 108, EBRTn = 101); Stage (2) 123 non-trial patients yet to receive radiotherapy (pre-treatment group), with 85 also surveyed post-radiotherapy. Patients traded-off risks of local recurrence in preference selection between TARGIT-IORT and EBRT. Results TARGIT-IORT patients were more accepting of IORT than EBRT patients with 60% accepting the highest increased risk presented (4%-6%) compared to 12% of EBRT patients, and 2% not accepting IORT at all compared to 43% of EBRT patients. Pre-treatment patients were more accepting of IORT than post-treatment patients with 23% accepting the highest increased risk presented compared to 15% of post-treatment patients, and 15% not accepting IORT at all compared to 41% of pre-treatment patients. Conclusions Breast cancer patients yet to receive radiotherapy accept a higher recurrence risk than the actual risk found in TARGIT-A. Measured patient preferences are highly influenced by experience of treatment received. This finding challenges the validity of post-treatment preference studies.
Original language | English |
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Article number | e12985 |
Number of pages | 10 |
Journal | European Journal of Cancer Care |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 2019 |
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Dive into the research topics of 'Patient preferences for adjuvant radiotherapy in early breast cancer are strongly influenced by treatment received through random assignment'. Together they form a unique fingerprint.Projects
- 1 Finished
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NHMRC 393703 TARGIT: Targeted intraoperative radiotherapy for early breast cancer
Joseph, D. (Chief Investigator), Saunders, C. (Chief Investigator), Bulsara, M. (Chief Investigator) & Chua, B. (Chief Investigator)
1/01/06 → 31/12/10
Project: Research