@inbook{0f79600b87154f08a2ef1373837ea5f5,
title = "Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers",
abstract = "Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research.",
keywords = "Mouse models of cancer, Patient-derived xenograft, Pediatric brain cancer, Preclinical models",
author = "Jessica Buck and Hilary Hii and Raelene Endersby",
note = "Publisher Copyright: {\textcopyright} 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2024",
doi = "10.1007/978-1-0716-3858-3_5",
language = "English",
isbn = "978-1-0716-3857-6",
series = "Methods in molecular biology (Clifton, N.J.)",
publisher = "Humana Press Inc.",
pages = "41--53",
editor = "Saad, {Mohamed I.}",
booktitle = "Patient-Derived Xenografts",
address = "United States",
edition = "1",
}
