Pathologic assessment and predictors of radioresponsiveness in locally advanced rectal cancer

Christine Tracey Hemmings

Research output: ThesisDoctoral Thesis

56 Downloads (Pure)

Abstract

Regression of rectal carcinoma following preoperative chemoradiotherapy is highly variable. No reliable predictors of treatment response are yet known, and existing systems for quantifying tumour regression are suboptimal. This project sought to better define regression and its relationship to clinical outcomes, and to investigate potential predictors of regression. Regression was shown to be a significant predictor of clinical outcome, and a new method of assessing tumour regression was attempted.
Expression of SPARC protein in pre-treatment biopsies was associated with subsequent regression. If verified, this will be the first identified predictive marker for tumour resonse to neoadjuvant chemoradiotherapy in rectal cancer.
Original languageEnglish
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Zeps, Nikolajs, Supervisor
  • Platell, Cameron, Supervisor
Award date22 Jun 2018
DOIs
Publication statusUnpublished - 2018

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