Paternal transgenerational nutritional epigenetic effect: A new insight into nutritional manipulation to reduce the use of antibiotics in animal feeding

Xinyi Li, Mengya Wang, Shimin Liu, Xiaodong Chen, Yu Qiao, Xiaojun Yang, Junhu Yao, Shengru Wu

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The use of antibiotics in animal feeding has been banned in many countries because of increasing concerns about the development of bacterial resistance to antibiotics and potential issues on food safety. Searching for antibiotic substitutes is essential. Applying transgenerational epigenetic technology to animal production could be an alternative. Some environmental changes can be transferred to memory-like responses in the offspring through epigenetic mechanisms without changing the DNA sequence. In this paper, we reviewed those nutrients and non-nutritional additives that have transgenerational epigenetic effects, including some amino acids, vitamins, and polysaccharides. The paternal transgenerational nutritional epigenetic regulation was particularly focused on mechanism of the substantial contribution of male stud animals to the animal industries. We illustrated the effects of paternal transgenerational epigenetics on the metabolism and immunity in farming animals and proposed strategies to modulate male breeding livestock or poultry.
Original languageEnglish
Pages (from-to)142-151
Number of pages10
JournalAnimal Nutrition
Volume11
DOIs
Publication statusPublished - Dec 2022

Fingerprint

Dive into the research topics of 'Paternal transgenerational nutritional epigenetic effect: A new insight into nutritional manipulation to reduce the use of antibiotics in animal feeding'. Together they form a unique fingerprint.

Cite this