Past, present, and future concepts of the choroidal scleral interface morphology on optical coherence tomography

The choroid is the most vascular tissue in the eye and it has been implicated in the pathophysiology of a variety of ocular diseases. A new era of research in the choroid began with the improved ability to visualize this layer and its inner and outer boundaries using spectral domain optical coherence tomography (OCT) with enhanced depth imaging and swept source OCT. The accuracy and precision of qualitative and quantitative assessments of the choroidal layer support the potential use of OCT-derived choroidal parameters for diagnosis, monitoring of disease progression, planning surgical access, and evaluating treatment response. Although there is increasing interest in measuring choroidal thickness, there is currently no consensus nomenclature to classify choroidal layers and boundaries. Furthermore, the definition and description of the choroidal scleral interface is inconsistent in the literature, contributing to interstudy variation in choroidal thickness measurements. The purpose of this review is to provide an overview of the literature on the definition of choroidal layers and choroidal scleral boundary, review the discrepancies, and harmonize the terminology so that a consensus nomenclature can be proposed.