Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System

Carole A. Bartlett, Melinda Fitzgerald

Research output: Contribution to journalArticle

Abstract

Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal aspect of the nerve leaves the ventral aspect initially undamaged but vulnerable to secondary degeneration, allowing study of tissue exclusively vulnerable to secondary degeneration. Thus the partial optic nerve transection model of secondary degeneration is a valuable tool to study the pathology of spreading damage following neurotrauma and can be used to assess potential efficacy of therapeutic strategies.

Original languageEnglish
Article number3118
Number of pages14
JournalBio-Protocol
Volume8
Issue number24
DOIs
Publication statusPublished - 20 Dec 2018

Cite this

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abstract = "Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal aspect of the nerve leaves the ventral aspect initially undamaged but vulnerable to secondary degeneration, allowing study of tissue exclusively vulnerable to secondary degeneration. Thus the partial optic nerve transection model of secondary degeneration is a valuable tool to study the pathology of spreading damage following neurotrauma and can be used to assess potential efficacy of therapeutic strategies.",
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Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System. / Bartlett, Carole A.; Fitzgerald, Melinda.

In: Bio-Protocol, Vol. 8, No. 24, 3118, 20.12.2018.

Research output: Contribution to journalArticle

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T1 - Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System

AU - Bartlett, Carole A.

AU - Fitzgerald, Melinda

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N2 - Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal aspect of the nerve leaves the ventral aspect initially undamaged but vulnerable to secondary degeneration, allowing study of tissue exclusively vulnerable to secondary degeneration. Thus the partial optic nerve transection model of secondary degeneration is a valuable tool to study the pathology of spreading damage following neurotrauma and can be used to assess potential efficacy of therapeutic strategies.

AB - Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal aspect of the nerve leaves the ventral aspect initially undamaged but vulnerable to secondary degeneration, allowing study of tissue exclusively vulnerable to secondary degeneration. Thus the partial optic nerve transection model of secondary degeneration is a valuable tool to study the pathology of spreading damage following neurotrauma and can be used to assess potential efficacy of therapeutic strategies.

KW - Neurotrauma

KW - Secondary degeneration

KW - Partial optic nerve transection

KW - Visual system

KW - Optic nerve

U2 - 10.21769/BioProtoc.3118

DO - 10.21769/BioProtoc.3118

M3 - Article

VL - 8

JO - Bio-Protocol

JF - Bio-Protocol

SN - 2331-8325

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