Projects per year
Abstract
Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively model injury and secondary degeneration to white matter tracts. Partial transection of the dorsal aspect of the nerve leaves the ventral aspect initially undamaged but vulnerable to secondary degeneration, allowing study of tissue exclusively vulnerable to secondary degeneration. Thus the partial optic nerve transection model of secondary degeneration is a valuable tool to study the pathology of spreading damage following neurotrauma and can be used to assess potential efficacy of therapeutic strategies.
Original language | English |
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Article number | 3118 |
Number of pages | 14 |
Journal | Bio-Protocol |
Volume | 8 |
Issue number | 24 |
DOIs | |
Publication status | Published - 20 Dec 2018 |
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Dive into the research topics of 'Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System'. Together they form a unique fingerprint.Projects
- 1 Curtailed
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Innovative and multi-disciplinary treatment strategies for secondary degeneration following neurotrauma
Fitzgerald, M.
NHMRC National Health and Medical Research Council
1/01/15 → 30/12/18
Project: Research