This thesis is broken into two main projects. Part One, completed under Professor Baker, details the synthesis and properties of transition metal complexes bearing N-heterocyclic carbene ligands. Several complexes were isolated, including a novel n6-bound, ruthenium-NHC complex. Its structural, biological and catalytic characteristics have been explored, with mild catalytic activity found. Part Two, completed under the supervision of Associate Professor Piggott, details the synthesis and structural elucidation of the natural product 'samoquasine A'. Herein, the true identity of samoquasine A was investigated, and unequivocally proven to be perlolidine. This work currently represents the most efficient synthesis of perlolidine to date.
|Doctor of Philosophy
|11 Feb 2018
|Unpublished - 2018
- Embargoed from 13/03/2018 to 13/03/2020. Made publicly available on 13/03/2020.