Abstract
This two-part thesis, reports on two drug discovery projects. Part I investigates analogues of a biphenyl natural product as antiviral agents. The optimisation of the synthesis of the natural product is discussed, as well as the synthesis and biological activity of more polar analogues. The second project concerns the discovery of novel trypanosomacidal agents based on an existing series of 1-(2-(2-phenylthiazol-4-yl)ethyl)ureas. The aim of this project was to further optimise this class of compounds, to produce more metabolically stable analogues and identify a suitable drug candidate. Significant improvement in trypanosomacidal potency was achieved, along with modest increases in metabolic stability.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Supervisors/Advisors |
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| Award date | 2 Oct 2017 |
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| Publication status | Unpublished - 2017 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - NEWSON Harriet Laura - 2017 - Part 1
This work is protected by Copyright. You may print or download ONE copy of this document for the purpose of your own non-commercial research or study. Any other use requires permission from the copyright owner. The Copyright Act requires you to attribute any copyright works you quote or paraphrase.
- THESIS - DOCTOR OF PHILOSOPHY - NEWSON Harriet Laura - 2017 - Part 2
This work is protected by Copyright. You may print or download ONE copy of this document for the purpose of your own non-commercial research or study. Any other use requires permission from the copyright owner. The Copyright Act requires you to attribute any copyright works you quote or paraphrase.