Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies

Paula Rios, Helen D. Bailey, Claire Poulalhon, Dominique Valteau-Couanet, Gudrun Schleiermacher, Christophe Bergeron, Arnaud Petit, Anne Sophie Defachelles, Gambart Marion, Nicolas Sirvent, Stéphane Ducassou, Caroline Munzer, Laurent Orsi, Brigitte Lacour, Jacqueline Clavel

Research output: Contribution to journalArticle

Abstract

Neuroblastoma (NB) is the most common extra-cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population-based case–control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1,783 controls from general population, frequency matched by age and sex, were interviewed on demographic, socioeconomic and perinatal characteristics, maternal reproductive story, and life-style and childhood environment. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. A meta-analysis of our findings with those of previous studies was also conducted. Maternal smoking during pregnancy was slightly more often reported for the cases (24.1%) than for the controls (19.7%) (OR 1.3 [95% CI 0.9–1.7]; summary OR from meta-analysis 1.1 [95% CI 1.0–1.3]. Paternal smoking in the year before child's birth were not associated with NB as independent exposure (OR 1.1 [95% CI 0.9–1.4] but the association was stronger when both parents reported having smoked during pregnancy (OR 1.5 [95% CI 1.1–2.1]. No association was observed with maternal alcohol intake during pregnancy (OR 1.0 [95% CI 0.8–1.4], summary OR from meta-analysis 1.0 [95% CI 0.9–1.2]. Our findings provide some evidence of an association between maternal smoking during pregnancy and NB and add another reason to recommend that women refrain from smoking during pregnancy.

Original languageEnglish
Pages (from-to)2907-2916
Number of pages10
JournalInternational Journal of Cancer
Volume145
Issue number11
DOIs
Publication statusPublished - Dec 2019

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Neuroblastoma
Alcohol Drinking
Smoking
Mothers
Pregnancy
Meta-Analysis
Age of Onset
Population
Life Style
Parents
Logistic Models
Odds Ratio
Alcohols
Demography
Parturition
Confidence Intervals
Neoplasms

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Rios, Paula ; Bailey, Helen D. ; Poulalhon, Claire ; Valteau-Couanet, Dominique ; Schleiermacher, Gudrun ; Bergeron, Christophe ; Petit, Arnaud ; Defachelles, Anne Sophie ; Marion, Gambart ; Sirvent, Nicolas ; Ducassou, Stéphane ; Munzer, Caroline ; Orsi, Laurent ; Lacour, Brigitte ; Clavel, Jacqueline. / Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies. In: International Journal of Cancer. 2019 ; Vol. 145, No. 11. pp. 2907-2916.
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title = "Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies",
abstract = "Neuroblastoma (NB) is the most common extra-cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population-based case–control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1,783 controls from general population, frequency matched by age and sex, were interviewed on demographic, socioeconomic and perinatal characteristics, maternal reproductive story, and life-style and childhood environment. Unconditional logistic regression was used to estimate pooled odds ratios and 95{\%} confidence intervals. A meta-analysis of our findings with those of previous studies was also conducted. Maternal smoking during pregnancy was slightly more often reported for the cases (24.1{\%}) than for the controls (19.7{\%}) (OR 1.3 [95{\%} CI 0.9–1.7]; summary OR from meta-analysis 1.1 [95{\%} CI 1.0–1.3]. Paternal smoking in the year before child's birth were not associated with NB as independent exposure (OR 1.1 [95{\%} CI 0.9–1.4] but the association was stronger when both parents reported having smoked during pregnancy (OR 1.5 [95{\%} CI 1.1–2.1]. No association was observed with maternal alcohol intake during pregnancy (OR 1.0 [95{\%} CI 0.8–1.4], summary OR from meta-analysis 1.0 [95{\%} CI 0.9–1.2]. Our findings provide some evidence of an association between maternal smoking during pregnancy and NB and add another reason to recommend that women refrain from smoking during pregnancy.",
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author = "Paula Rios and Bailey, {Helen D.} and Claire Poulalhon and Dominique Valteau-Couanet and Gudrun Schleiermacher and Christophe Bergeron and Arnaud Petit and Defachelles, {Anne Sophie} and Gambart Marion and Nicolas Sirvent and St{\'e}phane Ducassou and Caroline Munzer and Laurent Orsi and Brigitte Lacour and Jacqueline Clavel",
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Rios, P, Bailey, HD, Poulalhon, C, Valteau-Couanet, D, Schleiermacher, G, Bergeron, C, Petit, A, Defachelles, AS, Marion, G, Sirvent, N, Ducassou, S, Munzer, C, Orsi, L, Lacour, B & Clavel, J 2019, 'Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies' International Journal of Cancer, vol. 145, no. 11, pp. 2907-2916. https://doi.org/10.1002/ijc.32161

Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies. / Rios, Paula; Bailey, Helen D.; Poulalhon, Claire; Valteau-Couanet, Dominique; Schleiermacher, Gudrun; Bergeron, Christophe; Petit, Arnaud; Defachelles, Anne Sophie; Marion, Gambart; Sirvent, Nicolas; Ducassou, Stéphane; Munzer, Caroline; Orsi, Laurent; Lacour, Brigitte; Clavel, Jacqueline.

In: International Journal of Cancer, Vol. 145, No. 11, 12.2019, p. 2907-2916.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies

AU - Rios, Paula

AU - Bailey, Helen D.

AU - Poulalhon, Claire

AU - Valteau-Couanet, Dominique

AU - Schleiermacher, Gudrun

AU - Bergeron, Christophe

AU - Petit, Arnaud

AU - Defachelles, Anne Sophie

AU - Marion, Gambart

AU - Sirvent, Nicolas

AU - Ducassou, Stéphane

AU - Munzer, Caroline

AU - Orsi, Laurent

AU - Lacour, Brigitte

AU - Clavel, Jacqueline

PY - 2019/12

Y1 - 2019/12

N2 - Neuroblastoma (NB) is the most common extra-cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population-based case–control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1,783 controls from general population, frequency matched by age and sex, were interviewed on demographic, socioeconomic and perinatal characteristics, maternal reproductive story, and life-style and childhood environment. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. A meta-analysis of our findings with those of previous studies was also conducted. Maternal smoking during pregnancy was slightly more often reported for the cases (24.1%) than for the controls (19.7%) (OR 1.3 [95% CI 0.9–1.7]; summary OR from meta-analysis 1.1 [95% CI 1.0–1.3]. Paternal smoking in the year before child's birth were not associated with NB as independent exposure (OR 1.1 [95% CI 0.9–1.4] but the association was stronger when both parents reported having smoked during pregnancy (OR 1.5 [95% CI 1.1–2.1]. No association was observed with maternal alcohol intake during pregnancy (OR 1.0 [95% CI 0.8–1.4], summary OR from meta-analysis 1.0 [95% CI 0.9–1.2]. Our findings provide some evidence of an association between maternal smoking during pregnancy and NB and add another reason to recommend that women refrain from smoking during pregnancy.

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KW - alcohol

KW - case–control study

KW - childhood cancer

KW - Neuroblastoma

KW - risk factors

KW - tobacco

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SP - 2907

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