Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: Findings from the Childhood Leukaemia International Consortium (CLIC)

Madar Talibov, Ann Olsson, Helen Bailey, Friederike Erdmann, Catherine Metayer, Corrado Magnani, Eleni Petridou, Anssi Auvinen, Logan Spector, Jacqueline Clavel, Eve Roman, John Dockerty, Atte Nikkilä, Olli Lohi, Alice Kang, Theodora Psaltopoulou, Lucia Miligi, Javier Vila, Elisabeth Cardis, Joachim Schüz

Research output: Contribution to journalArticle

Abstract

Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.

Original languageEnglish
Pages (from-to)746-753
Number of pages8
JournalOccupational and Environmental Medicine
Volume76
Issue number10
DOIs
Publication statusPublished - 1 Oct 2019

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Magnetic Fields
Occupational Exposure
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Meta-Analysis
Logistic Models
Case-Control Studies
Mothers
Pregnancy

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Talibov, Madar ; Olsson, Ann ; Bailey, Helen ; Erdmann, Friederike ; Metayer, Catherine ; Magnani, Corrado ; Petridou, Eleni ; Auvinen, Anssi ; Spector, Logan ; Clavel, Jacqueline ; Roman, Eve ; Dockerty, John ; Nikkilä, Atte ; Lohi, Olli ; Kang, Alice ; Psaltopoulou, Theodora ; Miligi, Lucia ; Vila, Javier ; Cardis, Elisabeth ; Schüz, Joachim. / Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring : Findings from the Childhood Leukaemia International Consortium (CLIC). In: Occupational and Environmental Medicine. 2019 ; Vol. 76, No. 10. pp. 746-753.
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title = "Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: Findings from the Childhood Leukaemia International Consortium (CLIC)",
abstract = "Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95{\%} CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95{\%} CI 0.95 to 1.13) for ALL and 1.06 (95{\%} CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95{\%} CI 0.89 to 1.12) for ALL and 0.85 (95{\%} CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.",
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author = "Madar Talibov and Ann Olsson and Helen Bailey and Friederike Erdmann and Catherine Metayer and Corrado Magnani and Eleni Petridou and Anssi Auvinen and Logan Spector and Jacqueline Clavel and Eve Roman and John Dockerty and Atte Nikkil{\"a} and Olli Lohi and Alice Kang and Theodora Psaltopoulou and Lucia Miligi and Javier Vila and Elisabeth Cardis and Joachim Sch{\"u}z",
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Talibov, M, Olsson, A, Bailey, H, Erdmann, F, Metayer, C, Magnani, C, Petridou, E, Auvinen, A, Spector, L, Clavel, J, Roman, E, Dockerty, J, Nikkilä, A, Lohi, O, Kang, A, Psaltopoulou, T, Miligi, L, Vila, J, Cardis, E & Schüz, J 2019, 'Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: Findings from the Childhood Leukaemia International Consortium (CLIC)' Occupational and Environmental Medicine, vol. 76, no. 10, pp. 746-753. https://doi.org/10.1136/oemed-2019-105706

Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring : Findings from the Childhood Leukaemia International Consortium (CLIC). / Talibov, Madar; Olsson, Ann; Bailey, Helen; Erdmann, Friederike; Metayer, Catherine; Magnani, Corrado; Petridou, Eleni; Auvinen, Anssi; Spector, Logan; Clavel, Jacqueline; Roman, Eve; Dockerty, John; Nikkilä, Atte; Lohi, Olli; Kang, Alice; Psaltopoulou, Theodora; Miligi, Lucia; Vila, Javier; Cardis, Elisabeth; Schüz, Joachim.

In: Occupational and Environmental Medicine, Vol. 76, No. 10, 01.10.2019, p. 746-753.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring

T2 - Findings from the Childhood Leukaemia International Consortium (CLIC)

AU - Talibov, Madar

AU - Olsson, Ann

AU - Bailey, Helen

AU - Erdmann, Friederike

AU - Metayer, Catherine

AU - Magnani, Corrado

AU - Petridou, Eleni

AU - Auvinen, Anssi

AU - Spector, Logan

AU - Clavel, Jacqueline

AU - Roman, Eve

AU - Dockerty, John

AU - Nikkilä, Atte

AU - Lohi, Olli

AU - Kang, Alice

AU - Psaltopoulou, Theodora

AU - Miligi, Lucia

AU - Vila, Javier

AU - Cardis, Elisabeth

AU - Schüz, Joachim

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.

AB - Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.

KW - acute lymphoblastic leukemia

KW - acute myeloid leukemia

KW - case-control study

KW - elf-mf

KW - occupation

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U2 - 10.1136/oemed-2019-105706

DO - 10.1136/oemed-2019-105706

M3 - Article

VL - 76

SP - 746

EP - 753

JO - OEM Online

JF - OEM Online

SN - 1351-0711

IS - 10

ER -