Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK

C. Huoi, A.C. Olsson, T.J. Lightfoot, E.A. Roman, J. Clavel, B. Lacour, P. Kaatsch, H.E. Kromhout, R.C.H. Vermeulen, Susan Peters, H.D. Bailey, J. Schüz

Research output: Contribution to journalArticle

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Abstract

© 2014, Springer International Publishing Switzerland. Methods: We pooled data from three population-based case–control studies from Germany, France, and the UK. Cases were children aged up to 15 years and diagnosed with CNS tumor, and controls were frequency-matched by age and sex. Socio-demographic data and parental occupation around conception/pregnancy and at diagnosis were collected using standardized interviews, face-to-face or by telephone. A general population job-exposure matrix was used to assign a level of exposure to each job. Logistic regression models were fitted to compute odds ratios and 95 % confidence intervals. Results: Our study included 1,361 cases of CNS tumors and 5,500 controls. Paternal exposure to PAH, asbestos, and metals around conception was associated with an increased moderate risk of CNS tumors, although statistically non-significant. The association with exposure to asbestos around conception and diagnosis was stronger when fathers were exposed to high levels. Paternal exposure to DME and silica, and maternal exposure to PAH, DME, asbestos, silica, and metals, were not associated with an increased risk of CNS tumors. Conclusion: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies. Purpose: To assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational exposure to polycyclic aromatic hydrocarbons (PAH), diesel motor exhaust (DME), asbestos, crystalline silica, and metals, which are established carcinogens in adults.
Original languageEnglish
Pages (from-to)1603-1613
JournalCancer Causes & Control
Volume25
Issue number12
Early online date5 Oct 2014
DOIs
Publication statusPublished - Dec 2014

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Central Nervous System Neoplasms
Occupational Exposure
France
Germany
Paternal Exposure
Asbestos
Polycyclic Aromatic Hydrocarbons
Vehicle Emissions
Silicon Dioxide
Metals
Logistic Models
Maternal Exposure
Switzerland
Occupations
Telephone
Fathers
Carcinogens
Population
Odds Ratio
Demography

Cite this

Huoi, C. ; Olsson, A.C. ; Lightfoot, T.J. ; Roman, E.A. ; Clavel, J. ; Lacour, B. ; Kaatsch, P. ; Kromhout, H.E. ; Vermeulen, R.C.H. ; Peters, Susan ; Bailey, H.D. ; Schüz, J. / Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK. In: Cancer Causes & Control. 2014 ; Vol. 25, No. 12. pp. 1603-1613.
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abstract = "{\circledC} 2014, Springer International Publishing Switzerland. Methods: We pooled data from three population-based case–control studies from Germany, France, and the UK. Cases were children aged up to 15 years and diagnosed with CNS tumor, and controls were frequency-matched by age and sex. Socio-demographic data and parental occupation around conception/pregnancy and at diagnosis were collected using standardized interviews, face-to-face or by telephone. A general population job-exposure matrix was used to assign a level of exposure to each job. Logistic regression models were fitted to compute odds ratios and 95 {\%} confidence intervals. Results: Our study included 1,361 cases of CNS tumors and 5,500 controls. Paternal exposure to PAH, asbestos, and metals around conception was associated with an increased moderate risk of CNS tumors, although statistically non-significant. The association with exposure to asbestos around conception and diagnosis was stronger when fathers were exposed to high levels. Paternal exposure to DME and silica, and maternal exposure to PAH, DME, asbestos, silica, and metals, were not associated with an increased risk of CNS tumors. Conclusion: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies. Purpose: To assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational exposure to polycyclic aromatic hydrocarbons (PAH), diesel motor exhaust (DME), asbestos, crystalline silica, and metals, which are established carcinogens in adults.",
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Huoi, C, Olsson, AC, Lightfoot, TJ, Roman, EA, Clavel, J, Lacour, B, Kaatsch, P, Kromhout, HE, Vermeulen, RCH, Peters, S, Bailey, HD & Schüz, J 2014, 'Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK' Cancer Causes & Control, vol. 25, no. 12, pp. 1603-1613. https://doi.org/10.1007/s10552-014-0465-4

Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK. / Huoi, C.; Olsson, A.C.; Lightfoot, T.J.; Roman, E.A.; Clavel, J.; Lacour, B.; Kaatsch, P.; Kromhout, H.E.; Vermeulen, R.C.H.; Peters, Susan; Bailey, H.D.; Schüz, J.

In: Cancer Causes & Control, Vol. 25, No. 12, 12.2014, p. 1603-1613.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK

AU - Huoi, C.

AU - Olsson, A.C.

AU - Lightfoot, T.J.

AU - Roman, E.A.

AU - Clavel, J.

AU - Lacour, B.

AU - Kaatsch, P.

AU - Kromhout, H.E.

AU - Vermeulen, R.C.H.

AU - Peters, Susan

AU - Bailey, H.D.

AU - Schüz, J.

PY - 2014/12

Y1 - 2014/12

N2 - © 2014, Springer International Publishing Switzerland. Methods: We pooled data from three population-based case–control studies from Germany, France, and the UK. Cases were children aged up to 15 years and diagnosed with CNS tumor, and controls were frequency-matched by age and sex. Socio-demographic data and parental occupation around conception/pregnancy and at diagnosis were collected using standardized interviews, face-to-face or by telephone. A general population job-exposure matrix was used to assign a level of exposure to each job. Logistic regression models were fitted to compute odds ratios and 95 % confidence intervals. Results: Our study included 1,361 cases of CNS tumors and 5,500 controls. Paternal exposure to PAH, asbestos, and metals around conception was associated with an increased moderate risk of CNS tumors, although statistically non-significant. The association with exposure to asbestos around conception and diagnosis was stronger when fathers were exposed to high levels. Paternal exposure to DME and silica, and maternal exposure to PAH, DME, asbestos, silica, and metals, were not associated with an increased risk of CNS tumors. Conclusion: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies. Purpose: To assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational exposure to polycyclic aromatic hydrocarbons (PAH), diesel motor exhaust (DME), asbestos, crystalline silica, and metals, which are established carcinogens in adults.

AB - © 2014, Springer International Publishing Switzerland. Methods: We pooled data from three population-based case–control studies from Germany, France, and the UK. Cases were children aged up to 15 years and diagnosed with CNS tumor, and controls were frequency-matched by age and sex. Socio-demographic data and parental occupation around conception/pregnancy and at diagnosis were collected using standardized interviews, face-to-face or by telephone. A general population job-exposure matrix was used to assign a level of exposure to each job. Logistic regression models were fitted to compute odds ratios and 95 % confidence intervals. Results: Our study included 1,361 cases of CNS tumors and 5,500 controls. Paternal exposure to PAH, asbestos, and metals around conception was associated with an increased moderate risk of CNS tumors, although statistically non-significant. The association with exposure to asbestos around conception and diagnosis was stronger when fathers were exposed to high levels. Paternal exposure to DME and silica, and maternal exposure to PAH, DME, asbestos, silica, and metals, were not associated with an increased risk of CNS tumors. Conclusion: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies. Purpose: To assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational exposure to polycyclic aromatic hydrocarbons (PAH), diesel motor exhaust (DME), asbestos, crystalline silica, and metals, which are established carcinogens in adults.

U2 - 10.1007/s10552-014-0465-4

DO - 10.1007/s10552-014-0465-4

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VL - 25

SP - 1603

EP - 1613

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

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