Paraspeckles

Archa Fox, A.I. Lamond

Research output: Contribution to journalArticlepeer-review

199 Citations (Scopus)

Abstract

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men ε/β, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.
Original languageEnglish
Article numbera000687
Pages (from-to)277-290
JournalCold Spring Harbor Perspectives in Biology
Volume2
Issue number7
DOIs
Publication statusPublished - 2010

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