[Truncated] The integration of a complex network of signalling molecules promotes implantation of blastocyst and the development of placenta. These processes are crucial for a successful pregnancy and optimal fetal growth and development. The signalling network involves both cell-to-cell and cell-to-extracellular matrix communication. The family of secreted glycoprotein ligands, Wnts, plays a major role in regulating a wide range of biological processes, including embryonic development, cell fate, proliferation, migration, stem cell maintenance, tumour suppression, oncogenesis and tissue homeostasis.
|Publication status||Unpublished - Sep 2014|