Pangenomics in Microbial and Crop Research: Progress, Applications, and Perspectives

Sumit Kumar Aggarwal, Alla Singh, Mukesh Choudhary, Aundy Kumar, Sujay Rakshit, Pardeep Kumar, Abhishek Bohra, Rajeev K. Varshney

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Advances in sequencing technologies and bioinformatics tools have fueled a renewed interest in whole genome sequencing efforts in many organisms. The growing availability of multiple genome sequences has advanced our understanding of the within-species diversity, in the form of a pangenome. Pangenomics has opened new avenues for future research such as allowing dissection of complex molecular mechanisms and increased confidence in genome mapping. To comprehen-sively capture the genetic diversity for improving plant performance, the pangenome concept is further extended from species to genus level by the inclusion of wild species, constituting a super-pangenome. Characterization of pangenome has implications for both basic and applied research. The concept of pangenome has transformed the way biological questions are addressed. From understanding evolution and adaptation to elucidating host–pathogen interactions, finding novel genes or breeding targets to aid crop improvement to design effective vaccines for human prophy-laxis, the increasing availability of the pangenome has revolutionized several aspects of biological research. The future availability of high-resolution pangenomes based on reference-level near-com-plete genome assemblies would greatly improve our ability to address complex biological prob-lems.

Original languageEnglish
Article number598
Issue number4
Publication statusPublished - Apr 2022


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