TY - JOUR
T1 - Pangenomics Comes of Age
T2 - From Bacteria to Plant and Animal Applications
AU - Golicz, Agnieszka A
AU - Bayer, Philipp E
AU - Bhalla, Prem L
AU - Batley, Jacqueline
AU - Edwards, David
PY - 2020/2
Y1 - 2020/2
N2 - The pangenome refers to a collection of genomic sequence found in the entire species or population rather than in a single individual; the sequence can be core, present in all individuals, or accessory (variable or dispensable), found in a subset of individuals only. While pangenomic studies were first undertaken in bacterial species, developments in genome sequencing and assembly approaches have allowed construction of pangenomes for eukaryotic organisms, fungi, plants, and animals, including two large-scale human pangenome projects. Analysis of the these pangenomes revealed key differences, most likely stemming from divergent evolutionary histories, but also surprising similarities.
AB - The pangenome refers to a collection of genomic sequence found in the entire species or population rather than in a single individual; the sequence can be core, present in all individuals, or accessory (variable or dispensable), found in a subset of individuals only. While pangenomic studies were first undertaken in bacterial species, developments in genome sequencing and assembly approaches have allowed construction of pangenomes for eukaryotic organisms, fungi, plants, and animals, including two large-scale human pangenome projects. Analysis of the these pangenomes revealed key differences, most likely stemming from divergent evolutionary histories, but also surprising similarities.
UR - http://www.scopus.com/inward/record.url?scp=85076825006&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2019.11.006
DO - 10.1016/j.tig.2019.11.006
M3 - Review article
C2 - 31882191
SN - 0168-9525
VL - 36
SP - 132
EP - 145
JO - Trends in Genetics
JF - Trends in Genetics
IS - 2
ER -