Pangenomics Comes of Age: From Bacteria to Plant and Animal Applications

Agnieszka A Golicz, Philipp E Bayer, Prem L Bhalla, Jacqueline Batley, David Edwards

Research output: Contribution to journalReview articlepeer-review

131 Citations (Scopus)
1088 Downloads (Pure)

Abstract

The pangenome refers to a collection of genomic sequence found in the entire species or population rather than in a single individual; the sequence can be core, present in all individuals, or accessory (variable or dispensable), found in a subset of individuals only. While pangenomic studies were first undertaken in bacterial species, developments in genome sequencing and assembly approaches have allowed construction of pangenomes for eukaryotic organisms, fungi, plants, and animals, including two large-scale human pangenome projects. Analysis of the these pangenomes revealed key differences, most likely stemming from divergent evolutionary histories, but also surprising similarities.

Original languageEnglish
Pages (from-to)132-145
Number of pages14
JournalTrends in Genetics
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2020

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