Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry

Diego Preciado, Anna Granath, Jizhen Lin, Stéphanie Val, Arwa Kurabi, Nikki Johnston, Shyan Vijayasekaran, Tulio Valdez, Didier Depireux, Ann Hermansson

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Objectives: To update the medical literature on recent cellular and molecular advances in otitis media disease models with a principal focus on developments in the past 5 years. We also aim to explain recent translational advances in cellular and molecular biology that have influenced our understanding and management of otitis media. Data Sources: PubMed-indexed peer-reviewed articles. Review Methods: A comprehensive review of the literature was conducted with the term otitis media and the following search terms: molecular biology, cell biology, innate immunity, oxidative stress, mucins, molecular diagnostics. Included articles were published in the English language from January 1, 2010, to July 31, 2015. Implications for Practice: The molecular understanding of otitis media disease progression has rapidly advanced over the last 5 years. The roles of inflammation, mucins, and cell signaling mechanisms have been elucidated and defined. Advances in the field provide a plethora of opportunities for innovative molecular targeting in the development of novel therapeutic strategies for otitis media.

    Original languageEnglish
    Pages (from-to)S106-S113
    JournalOtolaryngology - Head and neck surgery
    Volume156
    Issue number4_suppl
    DOIs
    Publication statusPublished - 1 Apr 2017

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