Paediatric deceased donor kidney transplant in Australia: A 30-year review—What have paediatric bonuses achieved and where to from here?

Matthew P. Sypek, Christopher E. Davies, Amelia K. Le Page, Philip Clayton, Peter D. Hughes, Nicholas Larkins, Germaine Wong, Joshua Y. Kausman, Fiona Mackie

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Background: In this 30-year national review, we describe trends in DD transplantation for paediatric recipients, assess the impact of paediatric allocation bonuses and identify outstanding areas of need for this population. Methods: A retrospective review of all DD kidney only transplants to paediatric recipients (<18 years old) in Australia between 1989 and 2018 was conducted using deidentified extracts from the ANZDATA. Results: Of the 1011 kidney only transplants performed in paediatric recipients during the study period, 426 (42%) were from deceased donors. Paediatric candidates on the DD waiting list had consistently higher rates of transplantation and shorter time from dialysis initiation to transplantation compared with adult candidates (median 372 vs 832 days in 2018, for example). Donor characteristics remained more favourable for paediatric recipients, despite a decline in the overall quality of the donor pool. The mean number of HLA antigen mismatches for paediatric recipients of DD transplants increased each decade (2.86 [1989–1998], 3.85 [1999–2008], 4.01 [2009–2018]). Both patient and graft survival have improved for paediatric DD transplant recipients in the most recent era (5-year graft and patient survival 85% vs 65% and 99% vs 94%, respectively, for 2009–2018 vs 1999–2008). Conclusions: The current DD kidney allocation system in Australia provides rapid access to high-quality organs for paediatric recipients, and early graft loss has decreased significantly in recent years; however, additional targeted interventions to address HLA matching may improve long-term outcomes in this population.

Original languageEnglish
Article numbere14019
JournalPediatric Transplantation
Volume25
Issue number6
Early online date4 May 2021
DOIs
Publication statusPublished - Sept 2021

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