Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series

Bernd Niemann, Susanne Rohrbach, Mark R. Miller, David E. Newby, Valentin Fuster, Jason C. Kovacic

Research output: Contribution to journalReview articlepeer-review

228 Citations (Scopus)

Abstract

Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting. Here, we explore the role of different ROS sources arising in obesity and diabetes, and the effect of excessive ROS production on the development of cardiac lipotoxicity. In parallel, contaminants in the air that we breathe pose a significant threat to human health. This paper provides an overview of cigarette smoke and urban air pollution, considering how their composition and biological effects have detrimental effects on cardiovascular health.
Original languageEnglish
Pages (from-to)230-251
Number of pages22
JournalJournal of the American College of Cardiology
Volume70
Issue number2
DOIs
Publication statusPublished - 11 Jul 2017
Externally publishedYes

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