Oxidation products of arachidonic acid within lipoproteins and their effects on macrophage migration

Julie Proudfoot

doi:10.26182/5c89c2d34dbf3

Oxidation products of arachidonic acid within lipoproteins and their effects on macrophage migration

Julie Proudfoot

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Barden, Anne, Supervisor Mori, Trevor, Supervisor Croft, Kevin, Supervisor
Award date	9 Jan 2019
DOIs	https://doi.org/10.26182/5c89c2d34dbf3
Publication status	Unpublished - 2019

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10.26182/5c89c2d34dbf3

THESIS - DOCTOR OF PHILOSOPHY - PROUDFOOT Julie Margaret - 2019
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Cite this

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title = "Oxidation products of arachidonic acid within lipoproteins and their effects on macrophage migration",

abstract = "Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.",

keywords = "F2-Isoprostanes, Macrophages, CSF-1, Oxidized lipids, Macrophage migration, HDL, Lipoproteins, serum vs plasma isoprostanes",

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AU - Proudfoot, Julie

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N2 - Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.

AB - Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.

KW - F2-Isoprostanes

KW - Macrophages

KW - CSF-1

KW - Oxidized lipids

KW - Macrophage migration

KW - HDL

KW - Lipoproteins

KW - serum vs plasma isoprostanes

U2 - 10.26182/5c89c2d34dbf3

DO - 10.26182/5c89c2d34dbf3

M3 - Doctoral Thesis

ER -

Oxidation products of arachidonic acid within lipoproteins and their effects on macrophage migration

Abstract

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