Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.
|Qualification||Doctor of Philosophy|
|Award date||9 Jan 2019|
|Publication status||Unpublished - 2019|