Abstract
Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 9 Jan 2019 |
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| Publication status | Unpublished - 2019 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - PROUDFOOT Julie Margaret - 2019
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