Oxidation products of arachidonic acid within lipoproteins and their effects on macrophage migration

Research output: ThesisDoctoral Thesis

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Abstract

Oxidized lipids play an important role in the development of atherosclerosis and cardiovascular disease. We previously showed that high-density lipoproteins in circulating blood contain a particular class of oxidized lipids, called isoprostanes. This thesis examined where isoprostanes are located in high-density lipoproteins and how they affect macrophage migration, a key process in the progression of atherosclerosis. Isoprostanes were found in the neutral lipids and phospholipids of high- density lipoproteins and isoprostanes increased macrophage migration. My studies have shown that stimulation of macrophage migration by isoprostanes may have a significant influence on the progression of atherosclerosis and cardiovascular disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date9 Jan 2019
DOIs
Publication statusUnpublished - 2019

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